"Addictiveness" – measures and methods
Regulatory demands for information on the “addictiveness” of consumer nicotine or tobacco products and their component ingredients are now common. However there has been a notable lack of guidance regarding the core scientific constructs which are assumed to underlie “addictiveness”, what metrics exist or may need to be developed and what type of additional data, if any, may need to be generated. Based upon a review of the scientific literature this presentation will explore the theoretical basis of “addictiveness” and consider what information Regulators may wish to examine in reaching a determination of “addictiveness”. Firstly the historical background of “addictiveness” will be considered and how this relates to “addiction” and “abuse liability”. The presentation will then consider the lessons which may be learnt from the pharmaceutical industry (particularly in the development of pharmaceutical nicotine preparations) where the assessment of “abuse liability” is common if compounds are believed to exert a psychopharmacological effect. Historical “addictiveness” data relating to tobacco, nicotine and other consumer products are then discussed and recent relevant research explained. Finally a list of candidate measures which might be used in a determination of “addictiveness” will be presented, together with a palette of related methods.