The most frequently used method for the analysis of residual N-methylcarbamates in water, soils and plants is high performance liquid chromatography (HPLC) followed by a post-column reaction and fluorimetric detection. On dry tobacco, as well as the problems linked to this complex matrice, pirimicarb is frequently used and it is not fluorescent. To avoid this inconvenience and to simplify the methodology, the authors show that it is possible to simultaneously inject the extract destined for HPLC in gas chromatography, supplied a NPD detector. Under these conditions, pirimicarb and other N-methylcarbamates can be analysed in GC. Those, sensible to both detectors allow a self control of these two complementary methods. Thus, the residues of twelve N-methylcarbamates can be analysed in extracts coming from most types of tobacco cultivated.