Analysis of trimethylamine in mainstream cigarette smoke
Trimethylamine (TMA) is a small volatile amine present in cigarette smoke at low levels as a known combustion by-product. It is hydrophilic in nature and exists in pure form as gas at room temperature. Because of these characteristics, its relatively low concentrations in cigarette smoke, and its low molecular weight, this constituent presents a challenge for quantitation for cigarette smoke characterization. Methodology in the literature for trimethylamine in cigarette smoke as a matrix is limited. In order to develop a robust quantitative method, several platforms and extraction techniques were explored. We would like to present our novel approaches using different platforms such as GC-NPD, GC-MS, GC-MS/MS to achieve targets for sensitivity and selectivity, and to discuss limitations of the platforms and how their results confirm each other.