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TSRC, Tob. Sci. Res. Conf., 2023, 76, abstr. 39

Analyzing the relationships between topography, e-liquid usage, and pharmacokinetics in JUUL2 prototype devices

LIANG Qiwei(1); RIMMER L.(1); CHIEN J.(1); GOLDENSON N.(1); BLACK R.(1); SHIFFMAN S.(2); OLIVERI D.(3)
(1) Juul Labs, Inc., Washington, DC, USA; (2) Pinney Associates, Bethesda, MD, USA; (3) Independent Consultant

The latest JUUL2 prototypes come equipped with a new feature that enables it to record puffing typography parameters during product use. In a recent pharmacokinetic study involving 37 participants, two new prototype products were tested under both ad libitum and controlled use conditions, and the recorded data including device ID, puff count, puff duration and inter-puff intervals were downloaded from the devices after the study completion. As the weight change of JUUL2 pods, calculated as the difference between the pre-use weight and post-use weight, and PK parameters were also measured in the same study, the key question now is to what extent the device topography parameters correlate with pod weight change and PK parameters.

The device IDs were linked with the study subject numbers (without use of personal information). Descriptive statistics for the topography parameters were provided. Total puff duration was identified as a significant contributor to the variability in both pod weight change and AUC for Product I. Specifically, total puff duration accounted for 86% and 70% of the variability in pod weight change and 23% and 26% of the variability in AUC in the ad libitum and controlled conditions, respectively. For Product II, total puff duration was also found to significantly influence the variability in pod weight change and AUC, accounting for 82% and 46% of the variability in pod weight change and 56% and 33% of the variability in AUC in the two study conditions, respectively. The strong correlation between total puff duration and pod weight change is a good indication of the usefulness of the new feature.