Application of biokinetic modelling for in vitro to in vivo extrapolation (IVIVE) in chemical risk assessment
In vitro chemical safety testing methods offer the potential for efficient and economical tools to provide relevant assessments of human health risk. To realize this potential, methods are needed to relate in vitro effects to in vivo responses, without relying on in vivo animal testing. To this end, in vitro to in vivo extrapolation (IVIVE) is key. IVIVE is essentially representing two main streams: 1) Upscale of in vitro measurements from molecular reaction to full organ to be used in biokinetic-dynamic modelling (biological scaling), and 2) The linking of in vitro concentration response (endpoints/effect) to external exposure doses by means of biokinetic modelling. In the current presentation we will highlight the main concepts of IVIVE, report the main biokinetic models and illustrate the IVIVE approach using case studies that were published as part of the recent OECD PBK model Guidance document (OECD, 2021).