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TSRC, Tob. Sci. Res. Conf., 2023, 76, abstr. 20 (also presented at CORESTA SSPT2023)

Aromatic amines in the mainstream smoke of commercial cigars

JI Huihua; JIN Zhenyu; FENTON L.; SLONE S.; ZHANG Bing
University of Kentucky, Lexington, KY, USA

Aromatic amines are a class of carcinogenic compounds in tobacco smoke that are listed on the FDA list of harmful and potentially harmful constituents (HPHCs) in tobacco products and tobacco smoke. Six aromatic amines yields (1-aminonaphthalene (1-AN), 2-aminonaphthalene (2-AN), 3-aminobiphenyl (3-ABP), 4-aminobiphenyl (4-ABP), ortho-toluidine (o-TOL), o‑anisidine (o-ANI)) in the mainstream smoke from 23 commercial filtered cigars, 16 cigarillos, and 11 large cigars were determined with the solid-phase microextraction-coupled to gas chromatography triple quadrupole mass spectrometry (SPME headspace GC–MS/MS) method. The commercial cigars were smoked under Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) Recommended Method 64 using a linear cigar smoke machine. The aromatic amine yields in the mainstream smoke from 50 commercial cigars show high variation within and between the products. The averages of each aromatic amine yield in the filtered cigars, cigarillos, and large cigars are 108, 371, and 623 ng/cigar for o-TOL; 6, 14, and 22 ng/cigar for o-ANI; 65, 114, and 174 ng/cigar for 1-AN; 25, 59, and 87 ng/cigar for 2-AN; 6, 17, and 27 ng/cigar for 3- ABP; 8, 11, and 17 ng/cigar for 4-ABP, respectively. The relationship between aromatic amine and total particulate matter (TPM) was evaluated. On a per cigar basis, the aromatic amines have a good linear response with TPM. On a per mass of TPM basis, the ratios of aromatic amines and TPM were consistent.