FDA proposed a cigarette nicotine standard to make them “minimally addictive or nonaddictive”. Some research has shown reductions in cigarette consumption after switching to SPECTRUM® reduced nicotine content cigarettes (RNC). We do not know whether adult cigarette smokers (AS) would experience similar reductions in smoking with other types of RNC. This study examined AS consumption (N = 70) of their usual brand cigarette (UB), a normal nicotine control cigarette (NNC) prototype, and a RNC prototype (~90% lower than typical marketed cigarettes) under confined short-term (9-hours) usage conditions followed by 17 days of at-home use of the NNC or RNC prototype. A linear mixed model revealed a significantly greater average (±SD) number of RNC smoked relative to UB under short-term usage conditions (13.2±4.7 vs. 12.3±3.9, p < 0.05). No significant difference between the number of RNC and NNC (13.2±4.7 vs. 12.9±4.3, p > 0.05) smoked was observed during short-term usage. RNC and NNC usage did not differ statistically during longer-term use, with average cigarettes per day of 19.6±11.2 and 18.5±10.2, respectively. Incoming cigarettes per day and stated willingness to use the products again at the end of short-term usage appeared to influence smoking behavior during longer-term use of the RNC and NNC prototypes. Limitations of this study include small sample size, short observation period, and no biochemical verification of study compliance. Results of this study demonstrate an increase in consumption of RNC relative to UB under short-term confined usage conditions and similar consumption to a NNC during longer-term ambulatory use. These findings diverge from previously published ambulatory studies with the SPECTRUM® RNC that reported reduction in smoking behavior relative to NNC and UB conditions.