Twenty-two major cigarette smoke components were measured using six HPLC methods : - volatile carbonyls were analysed after reaction with 2,4 DNP (2,4 dinitrophenylhydrazin). HPLC analysis was achieved on a C18-type column with elution gradient.- a-dicarbonyled components were analysed after derivatization with ortho-phenylenediamine. Separation of formed quinoxalins was achieved on silica in isocratic mode. - aliphatic acids were analysed after esterification using para-bromophenacyl bromide. HPLC analysis was achieved on a C18-type column with elution gradient. - phenols were analysed after derivatization using amino-4-antipyrine. Separation of formed derived products was achieved on silica in isocratic mode. - diphenols were analysed after reaction with n-butylamine. Separation of formed derived products was achieved on silica in isocratic mode. - aliphatic amines were analysed after derivatization with NBD-Cl (4-chloro 7-nitrobenzo 2-oxa 1,3-diazole). Separation of formed derived products was achieved on silica in isocratic mode. In all cases the used detection mode was visible-UV absorption. Thirty-seven commercial cigarettes from the European Union and Switzerland were analysed with these methods. The methods for the analysis of multidimensional data (main component analysis, classifications and discriminating factorial analysis) allow the classification of these products according to their type of blend (American, European, Virginia).