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TSRC, Tob. Sci. Res. Conf., 2023, 76, abstr. 34

Comparative quantitative health risk assessment (QRA) of a temperature-regulated nicotine salt-based connected ends product with reference cigarette: aerosol cancer and non-cancer risks

Chemular Inc., Hudson, MI, USA

The Glas G2 ENDS is a temperature-regulated nicotine salt pre-filled disposable pod connected system (Glas system). This work adopted the QRA approach to evaluate and present a comparison of reduced exposure (selective HPHCs) and corresponding potential cancer and non-cancer risks for the Glas G2 system with tobacco, menthol and non-tobacco-non-menthol formulations in comparison to the reference cigarette (3R4F) machine smoked/vaped under non-intense and intense puffing conditions.

Exposure concentrations (EC) were estimated assuming a lifetime continuous exposure using the equations.

3R4F cigarette:   AC × CPD × ED × EF / DIR × AT

Glas ENDS:        AC × (PC × PV) × ED × EF / DIR × AT

where EC, exposure concentration; AC, analyte concentrations under non-intense and intense conditions; CPD, cigarettes per day (20 for 3R4F); E, exposure duration (64.4 years); EF, exposure frequency (365 days); DIR, daily inhalation rate (20 m3/day); AT, averaging time (25550 days); PC, puff count (worst-case 400 puffs), and PV, puff volume (Glas: 0.055 L non-intense and 0.11 L intense and 3R4F: 0.035 L ISO non-intense and 0.055 L Heal Canada intense).

Non-cancer risks were quantified using the hazard quotient (HQ) approach and cancer risks were estimated by calculating the incremental lifetime cancer risk (ILCR), utilizing non-cancer and cancer toxicity values issued by government agencies or published in peer-reviewed literature.

Data revealed that, the modelling of exposure to HPHCs in Glas ENDS products aerosols lead to a marked reduction when compared to the smoke from 3R4F reference cigarette at both non-intense and intense vaping conditions, indicating the potential for significant reduced (>99%) non-cancer and cancer health hazard risks.