Flue-cured tobacco (Nicotiana tabacum L. cv. McNair 944) was fertilized with liquid nitrogen (N) either in two applications or metered through a center-pivot irrigation system during the first nine weeks after transplanting. These treatments were compared with a control treatment of tobacco fertilized with conventional granular fertilizer applied in two bands near the plants. Total N for the control plots and treatments with split applications of N were applied at 34 kg N/ha. Whereas, the metered liquid fertilizer was applied at a total of 34, 48, or 68 kg N/ha. Tobacco grown using liquid N was comparable in both yield and quality to tobacco grown using granular fertilizer. Even though the results were inconsistent among years, overall, none of the treatment practices produced tobacco that was different from tobacco produced by any other treatment. All of the fertilization systems were comparable for the production of tobacco, implying that chemigation of N fertilizer is a viable management option for the production of flue-cured tobacco.