The US FDA’s Tobacco Products Advisory Committee (TPSAC) list of harmful and potentially harmful compounds in mainstream smoke includes eleven compounds that may be considered as volatile organic compounds (VOCs). To analyze this wide range of compounds we wanted to apply CORESTA Recommended Method No. 70 “Determination of selected volatile organic compounds in the mainstream smoke of cigarettes” to the analysis of 1,3-butadiene, vinyl chloride, ethylene oxide, propylene oxide, furan, acrylonitrile, isoprene, nitromethane, vinyl acetate, benzene, and toluene in mainstream cigarette smoke. We will present the results of our method validation study including the trapping efficiency for each compound under ISO and Canadian Intense smoking conditions. We will also present data on the stability of ethylene and propylene oxide using several trapping solvents. Finally we will present data from our laboratory control charts and discuss the practical limitations of using liquid impingers to trap low level VOCs in mainstream cigarette smoke.