Traditional tobacco cultivation starts with transplanting of young plants from a nursery into open fields. This operation, linked to the cool spring weather in many countries, is very costly if we are dealing with tobacco for protein. In fact, the optimal final density of plants per hectare, in this purpose, is around 200,000 against the traditional density of 30,000. In order to lowering the agronomical costs, we tested the possibility of direct seeding tobacco on open fields, utilizing coated and uncoated tobacco, in two different periods. The final results show the possibility of growing tobacco by direct seeding, on clayloam soil in Central Italy. The achieved final density of the crop was 200,000 plants per hectare and it was possible to obtain in the same year two harvests with a total yield of dry matter of 8.7 ton/ha. In the paper is discussed all the agronomic techniques utilized in the trials. The economical evaluation of the suggested technique is under investigation.