There are a number of different smoking machines and exposure chamber combinations used by our industry to assess the toxicological impact of cigarette smoke in vitro. The amount of smoke delivered to cells within an in vitro exposure system can be presented in many ways: ratios of smoke to air, mixing airflow rate, vacuum rate, percentage or fraction. However, dosimetry (the quantifiable amount of smoke cells are directly exposed to) is more relevant and is becoming increasingly important in the field of cigarette smoke in vitro assessment. Dosimetry techniques will hopefully bridge the gap between different technologies and allow cross-platform comparisons. Installed into various exposure chambers, quartz crystal microbalance (QCM) technology has allowed us to quantify cigarette smoke particulate dose in vitro. For example, 4 QCMs installed into the Vitrocell 6PT-CF exposure module enabled quantification of whole smoke deposited mass at a range of diluting airflows (0.25 - 4.0 L/min) resulting in 24.00 ± 2.00 μg/cm² - 1.13 ± 0.03 μg/cm² deposited particulate mass (3R4F cigarettes). Moreover, QCM tools have enabled the quality control of smoke runs and highlighted limitations/improvements to established whole smoke methodologies. Furthermore, for the first time we are able to perform direct comparisons of whole smoke particulate dose delivered from different in vitro whole smoke exposure systems: the Borgwaldt RM20S and Vitrocell VC 10. We can demonstrate that QCM technology is a reliable, effective and simple tool that can accurately quantify smoke particulate deposition in real-time, in vitro. Additionally, QCM data can be used to unify in vitro toxicological data irrespective of exposure system.