Mesoporous silica materials, such as SBA-15, are attracting increasing interest in the last years. Our research group has focused in their capability for reducing the toxic compounds generated in the smoking process when mixed with tobacco. By tuning the mixing time and intensity, temperature and other variables, SBA-15 may be prepared with different morphologies. Different SBA-15 have been synthesized with fiber like morphology, spherical particles, platelets and rods. All these materials have been added to 3R4F tobacco and mixed thoroughly. The conditioned mixtures have been rolled in cigarettes and smoked according the ISO 3308 standard. The mainstream tobacco smoke has been collected in two fractions, i.e.: the gas and the condensed particulate matter and analyzed by GC/MS. The results have been compared with samples prepared in a similar way but not including any catalysts, in order to study the effect that the structure of the SBA-15 on the reduction of the compounds generated. SBA-15 is capable of reducing most of the compounds present in the mainstream tobacco smoke. Spherical and rod SBA-15 yield significant reductions in tar and CO, but the greatest reductions were achieved iin the presence of fiber-like and platelet SBA-15: These materials can reduce around 62 and 60% of the condensed fraction collected in Cambridge filters, and 20-25% of CO.