Experiments were conducted at 16 locations in 1996-97 to evaluate the effects of a new herbicide, sulfentrazone, on weed control (primarily Cyperus spp and Ipomoea spp) and phytotoxicity in flue-cured tobacco. Sulfentrazone treatments were compared to a cultivated check and commonly used herbicides - pebulate, clomazone, and pendimethalin. Sulfentrazone provided excellent control of Cyperus spp, Ipomoea spp, and Amaranthus spp. Grass control with sulfentrazone was significantly lower than that from clomazone and pendimethalin, but better than that from pebulate. Phytotoxicity from sulfentrazone was observed when applied post-transplant and occasionally from pretransplant-incorporated. However, phytotoxicity was minimal and weed control was acceptable when sulfentrazone was applied to the soil surface prior to transplanting.