Azoxystrobin (Quadris) was evaluated for disease control in burley tobacco from 1998 to 2000. Activity on blue mold was evaluated each year. Additional test were conducted comparing azoxystrobin and mefenoxam (Ridomil Gold) for black shank control in 1999 and 2000. Azoxystrobin reduced the incidence of blue mold in one location and target spot in another in 1998. Weather fleck attributed to azoxystrobin was minimal and localized on lower leaves. In 1999, azoxystrobin reduced the incidence of blue mold and improved vigor and survivability in a black shank infested field. Yields were superior in areas treated with azoxystrobin compared to mefenoxam under drought conditions. In 2000, more normal weather reduced the incidence of black shank and improved the performance of mefenoxam. Azoxystrobin alone did not perform as well as mefenoxam, but in combination with mefenoxam out performed either alone. Azoxystrobin treated plants in blue mold tests had a higher incidence of weather fleck than seen in prior years. Azoxystrobin decrease blue mold incidence when compared to an untreated check and dimethomorph (Acrobat MZ) treated plots. However, Azoxystrobin rotated with acibenzolar-S-methyl (Actigard) further reduced blue mold incidence and improved yields significantly.