Recently, viable seed from various weed species has been found in tobacco exports, initiating great concern in foreign markets and a zero tolerance policy. University Specialists believe the majority of weed seed contamination is a result of mechanized harvest. At present, farmers have a variety of management options, such as cultivation, herbicide application, and hand weeding, to reduce weed pressure and lower seed bank populations for future years. However, the spectrum of herbicide options for tobacco is extremely limited, specifically for post-transplanting application. An evaluation of non-tobacco labeled herbicides for late season application is greatly needed to give farmers alternative strategies in weed management. Research was initiated at the Lower Coastal Plain Research Station (LCPRS) and the Upper Coastal Plain Research Station (UCPRS) in 2014. Treatments were arranged in a randomized complete block design and replicated four times. Eight different herbicides were evaluated, each at two different application timings: before topping and after first harvest. The eight herbicides were as follows: Dual Magnum, Spartan, Envoke, Reflex, Liberty, Callisto, Lorox, and Aim. A ninth herbicide, Poast, was applied after first harvest only and a control plot of Spartan + Command (Pre-T only) was included as well. Applications were made with a backpack sprayer containing a twenty inch boom and two Teejet VisiFlo flat spray tip nozzles. Application occurred at a spray volume of 20 gallons/acre. Spray applications covered the row middles as well as a portion of the tobacco bed. Product rates were based upon NCSU recommendations. Following application, weed control efficacy, crop injury, leaf yield, quality, value, and chemistry were quantified. In 2014, herbicide injury was observed in before topping applications of Liberty (3.75%), Callisto (12.50%), and Aim (2.50%) at UCPRS; however, leaf yield was not affected. Palmer amaranth suppression ranged from 95-100% following application for all treatments. (Reprinted with permission)