In past years the flavorful components from flue-cured, burley, and Turkish tobaccos have been extensively examined and numerous publications written. Considerable information is now available to tobacco flavorists about the most desirable components needed to enhance the unique flavors of these tobaccos. However, very little is known about Maryland tobacco. Although Maryland is not used extensively, it nevertheless is believed to impart uniqueness to smoke. Consequently, a study was undertaken to determine if Maryland had any unique components not found in other tobaccos. Maryland tobacco was extracted with methylene chloride and the extract after removal of the methylene chloride was partitioned between hexane and 90/10 methanol/water. The methanol/water portion was fractionated by preparative liquid chromatography. The resulting fractions were analyzed by GC and GC/MS. In addition, an essential oil analysis of Maryland tobacco was carried out. The results from these studies were compared to the results of similar studies done with burley and flue-cured tobaccos. Approximately 142 components were identified and compared. Major differences between Maryland and flue-cured, between Maryland and burley low-stalk leaves, between Maryland and burley middle-stalk leaves, and the uniqueness of Maryland will be discussed in this paper.