Rules in force make necessary to verify the compliance of tobacco and tobacco products with the maximum levels allowed for pesticide residues. Owing to the wide range of pesticides recommended for tobacco and to the need for analysing so many samples, the use of analytical methods suitable for specificity, sensitivity and reproducibility as well as economical in terms of both time and cost, is advisable. Few methods are already available for the determination of pesticide multiresidues in tobacco; among them, those for the organochlorines, the pyrethroids and the carbamates, which group the pesticides according to the chemical type of the active ingredient. This study reports on a GC method developed for the multiresidue determination of some of the most used tobacco pesticides. The two stages of this systematic study are detailed. In the first one, a procedure providing for both a single extraction and the same GC analysis conditions was defined by injecting single and multiple pesticide standards on a Megabore DB1 column and by the use of a TSD detector. Then, tobacco samples ascertained to be free from the pesticides under examination were fortified with them and analysed; the recoveries were evaluated. This method resulted suitable for the determination of residues of Benalaxyl, Benfluralin, Dazomet, Diphenamid, Isopropalin, Metalaxyl, Methiocarb, Penconazole, Pendimethalin, Pirimicarb in tobacco.