The JUUL Nicotine Salt Pod System (NSPS) has no user modifiable settings and is temperature regulated to minimize the generation of combustion related byproducts.

Aerosol generated from NSPS pods using a cotton wicking material was evaluated for harmful and potentially harmful constituents (HPHCs).

Seven flavors (tobacco, mint/menthol, and fruit flavors; 9 mg/mL nicotine) were analyzed for HPHCs listed in the U.S. FDA premarket tobacco application (PMTA) draft guidance document for ENDS. Testing was conducted by an accredited ISO 17025 laboratory using validated methods. Machine topography was 70 mL volume, 3 second puff duration, and 30 second inter-puff interval. Each analytical result was generated using a unique pod with 10 replicates collected for each assay. A panel of 22 analytes from six categories of HPHCs was assessed: tobacco specific nitrosamines (TSNAs), polyaromatic amines (PAAs), polyaromatic hydrocarbons (PAHs), carbonyls, volatile organic compounds (VOCs), and metals. Comparator reference combustible cigarettes (3R4F) were also evaluated.

HPHCs were reduced by 99 % in NSPS aerosol vs. mainstream smoke of the 3R4F comparator cigarette. The majority (95 %) of NSPS aerosol analytes were below the level of quantification. Notably, VOCs (acrylonitrile, benzene, 1,3-butadiene, isoprene, and toluene) and select carbonyls (diacetyl, acetyl propionyl, and crotonaldehyde) were uniformly below the level of detection in the aerosol generated by all seven flavors.

Consistent with previous testing, NSPS pods using a cotton wicking material demonstrated significant reductions in HPHCs on a puff-for-puff basis compared to reference combustible cigarettes.