The main fertilizer and irrigation management practices and contents of heavy metals (Cr, Ni, Cu, Zn, As, Cd and Pb) in main fertilizers for tobacco production in Circum-Shennongjia areas were studied by means of investigation and sample analysis, the introduction of the mentioned heavy metals into tobacco growing soils in these areas were estimated and the influences of fertilizers were discussed. The results showed that among the 16 test fertilizers, the detectable rates of Cr, Ni and Pb were the highest (93.75%), and that of Cd was the lowest (12.50%), which was only detectable in two phosphate fertilizers. The heavy metal contents in potassium fertilizers were lower, which did not affect the heavy metal accumulation in soil; while several heavy metal contents in phosphate fertilizers were higher, especially Cd, whose content might reach 0.88 mg/kg, and the application of phosphate fertilizer in large volume might adversely affect the Cd control in tobacco leaf. Cr, Ni, Cu, Zn, As, Cd and Pb introduced into soils in Circum-Shennongjia areas per tobacco growing season averaged 12.96, 5.67, 11.55, 50.03, 4.98, 0.05, and 19.16 g/hm², respectively. Among the four kinds of fertilizer, phosphate fertilizer played an important role in heavy metal introduction with the input rate of above 50% (except for Zn); tobacco special fertilizer was the next main carrier of Cr and As with the average input rate of above 40%; cake fertilizer contributed for about 50% of Cu and Zn input.