In certain flue-cured tobacco zones of India, quick ripening is a problem, whilst, in some other zones slow ripening is a constraint. To improve the ripening pattern in different zones, field experiments were carried out using ripening agents like α amylase, β amylase and Glucosoidase. These enzymes were sprayed at a concentration of 100 ppm each. Simultaneously, to retard the fast ripening, Sodium Benzoate (200 ppm) Propyl galate (200 ppm), Cobalt Chloride (100 ppm) and Kinetin @ 10 ppm and 20 ppm were tested during 1999-2000 and 2000-2001 seasons in four zones. The detailed physical parameters like production of leafy tobacco to luggy tobacco, the effect of enzymes on conversion of starch in hastening the ripening / the effect of chemicals in retarding the ripening wore analysed. The yield and grade out turns were also recorded which showed that α amylase and β amylase appear to be more promising in hastening the ripening whilst Kinetin and Cobalt Chloride appeared to retard quick and false ripening. They have also shown their effect on physical qualities. The percentage of ripe leaf increased in a amylase and β amylase whilst there was an insignificant decrease in yield because of the ripening factor. The details of the changes that occurred in the chemical composition and physical characteristics in relation to the manufacturability will be discussed in the paper.