Photoionisation time of flight mass spectrometry (PI-TOFMS) is well suited for online characterisation of tobacco smoke. Depending on the photoionisation method (single photon ionisation, SPI or resonance-enhanced multiphoton ionisation, REMPI) smoke constituents such as butadiene, acetaldehyde, naphthalene, phenol or polycyclic aromatic hydrocarbons (PAH, by REMPI) can be detected with high time resolution (puff-resolved). With the increased (legal) availability of marihuana/cannabis and THC containing smoking products not only for medical purposes, the interest in understanding the release processes of the active smoke constituents is increasing as well. Puff-by-puff emissions analysis of different products (‘joints’) filled with tobacco mixtures containing dried marihuana flowers, leafs or hashish were performed to investigate the release profile of THC and related smoke constituents in comparison to nicotine as the main active compound of the added tobacco. Within this study, a Laser PI-TOF system (Photonion GmbH, Schwerin/Germany) in REMPI mode was used coupled to a LM1 smoking machine (Borgwaldt KC, Hamburg/Germany). The REMPI methodology enables focusing on aromatic structures primarily relevant for this investigation. Smaller molecules being present in higher concentrations in smoke (e.g. aldehydes), which could lead to a suppression of the target smoke constituents during the measurement, are suppressed effectively compared to SPI (single photon ionisation). Environmental gases such as oxygen or nitrogen are suppressed by photoionisation anyway. Furthermore, the present study evaluates the influence of activated carbon filters, which are becoming more and more popular to reduce certain smoke constituents, such as PAHs (polycyclic aromatic hydrocarbons), in mainstream smoke of any combustible product.