Market survey of modern oral nicotine products: determination of select HPHCs and comparison to traditional smokeless tobacco products
In an effort to combat the risks associated with traditional tobacco products, tobacco science and product innovation has been redirected towards providing the consumer with products that may limit their potential exposure to harmful or potentially harmful constituents (HPHCs). Among these product innovations are modern oral nicotine products (MONPs), or tobacco-free nicotine products (TFNPs). This product class aims to deliver nicotine while reducing the consumer’s potential for toxicant exposure. This body of work sought to investigate the potential for select HPHC exposure (tobacco-specific nitrosamines, carbonyls, benzo[a]pyrene, nitrite, metals) from MONPs and to compare it to that from traditional tobacco products. Given the recent push towards reducing the consumer’s potential risk, this work expands on previously published studies both in terms of diversity of products assessed and analytes tested. In total, twenty-one unique MONPs were assessed and compared to four traditional tobacco products.
We found that there was a difference in the potential exposure based on the MONP filler—plant material vs granulate/powder. Typically, the HPHC levels observed in plant-based MONPs were higher than those observed for granulate/powder products with this trend most significant within the metals analysis. Here, the observed levels of select metals were generally higher in plant-based MONPs, the levels of which were, in some instances, also greater than those seen in traditional smokeless tobacco products. Generally, the overall HPHC levels observed in MONPs were at or below those levels observed in traditional tobacco products.