Is a method to determine polycyclic aromatic hydrocarbons in cigarette smoke applicable to aerosols generated from heated tobacco products?
The market offers various new generation products, including heated tobacco products. In order to measure constituents in the aerosol of such products, methods developed for cigarette smoke were investigated for their applicability.
This study is focused on the determination of polycyclic aromatic hydrocarbons (PAHs) in aerosols generated from heated tobacco products.
We have developed and validated a PAH method in cigarette mainstream smoke using ISO and intense smoking regimes by applying GC-MS/MS. The purpose of this study was to investigate how to adapt a method originally developed and validated for the measurement of PAHs in mainstream cigarette smoke condensate for the measurement of aerosols from heated tobacco.
Potential matrix effects and sources of contamination were a focus of this study as PAH levels are likely to be significantly lower compared to yields obtained from cigarette smoke.
An experiment in which aerosols collected on Cambridge filter pads (CFP) were spiked with PAHs was carried out in order to clarify these questions.
Furthermore, when the accuracy and precision of the adjusted method were compared with the original validation data obtained from cigarette smoke it was found that the tolerance intervals were comparable to those determined for cigarette smoke condensates. However, as the PAH emissions of such products are expected to be significantly lower than those in smoke condensates, particular attention was given to analytical criteria such as blank levels, signal/noise ratio (S/N) and specificity. These analytical criteria will be highlighted for each of these different types of products.
 V. Troude et al, HPHCs-validation of method: limitations in the “accuracy profile”, 68th TSRC, 2014