For decades, synthetic agrochemicals were the major components in tobacco crop protection. Most of these products had the advantage of efficacy, a knock-down effect and a broad spectrum of activity. Thus, for example, methyl bromide, used as a soil fumigant, could take care of all soil insect pests, nematode pests and soil pathogens at the seedling production stage. Equally other fumigants such as Ethylene dibromide (EDB), 1,3-Dichloropropane (1,3D) were relied upon heavily to protect transplants after which the equally effective organophosphate and carbamate group of pesticides could be used to protect the crop till harvest. However, due to issues of increased regulatory demands, environmental and worker protection concerns and requirements for sustainability in tobacco production, most of these chemical groups are no longer acceptable for use. Focus has been shifted to greener crop protection agents and other innovative methods that reduce levels of residues in the final leaf product and protect the environment and workers. In this paper we show the trends in tobacco crop protection in Zimbabwe by highlighting the changes in pesticide classes used and the integration of other pest control strategies over the past two decades.