Quantitative analysis of organic compounds in gas phase of mainstream cigarette smoke with on-line atmospheric pressure chemical ionisation tandem mass spectrometry
In order to measure selected organic compounds in cigarette smoke which might possess potential risks to human health and the environment, a tandem mass spectrometry method was developed and applied in the on-line analysis of mainstream cigarette smoke (MSS). After passing through a Cambridge filter, the gas phase of MSS was directed into the APCI ion source via the inlet end of the mass spectrometer. A commercial single-port smoking machine and APCI ion source were modified to achieve on-line single puff or puff-by-puff analysis of MSS, and seven organic compounds in gas phase of MSS were qualitatively and quantitatively analysed. The results showed that the calibration curves of the seven compounds exhibited good linear relations (R2>0.99) with the limits of detection from 0.016 to 2.05 ng/mL and the relative standard deviations (RSDs) from 2.63% to 8.89%. This method is simple in operation and features fast response, high sensitivity and good repeatability, and it is suitable for on-line analysis of organic compounds in MSS.