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TSRC, Tob. Sci. Res. Conf., 2023, 76, abstr. 44

A quantitative risk assessment approach to evaluate relative health risks of electronic cigarettes vs. combustible cigarettes

LIU C.(1); BERNAL A.(2); HUANG Yilang(3); LIU Chuan(4); GRAFF D.(5); JIAN Xingtao(3)
(1) RiskWise Solution, Princeton, NJ, USA; (2) ToxCreative, Laguna Hills, CA, USA; (3) RELX Technology, Shenzhen, China; (4) Pinevale, Southampton, UK; (5) Cheerain HK Limited, Hong Kong, China

Electronic cigarettes (e-cigarettes) heat a nicotine-containing e-liquid that could significantly reduce the number and levels of inhaled toxicants compared to combustible cigarettes. A framework for assessment of potential health risk of e-cigarette aerosol emissions can support regulatory evaluation and inform regulatory decisions of whether an e-cigarette product meets regulatory agency requirements. This quantitative risk assessment (QRA) approach evaluated relative cancer and noncancer health risks associated with the use of RELX Infinity Tobacco compared with Kentucky 1R6F reference cigarettes and Vuse Alto Golden Tobacco. The e-cigarette aerosol samples were analyzed for the U.S. Food and Drug Administration recommended harmful and potentially harmful constituents (HPHCs) and target constituents under both non-intense and intense puffing regimens. Machine-generated HPHC yields for 1R6F reference cigarette mainstream smoke were obtained from the literature. Toxicity reference values for HPHCs and target constituents were obtained from regulatory and public health agency databases. Exposure concentrations were estimated under “typical “ and “heavy” scenarios by utilizing exposure parameters specific to adult tobacco product consumers and standard default exposure parameters for human health risk assessment. The potential health risks associated with inhalation of HPHC and target constituent emissions from e-cigarettes and combustible cigarettes for adult consumers were assessed and compared by integrating the exposure and the dose-response assessments into quantitative estimates of health hazards and cancer risk. The QRA results indicated that estimated risks of vaping RELX and comparator e-cigarette products for cancer and respiratory, cardiovascular, reproductive and developmental toxicity were at least 97% lower than those of cigarette smoking. This study demonstrates that QRA is a practical tool for evaluating relative health risks of e-cigarettes to support regulatory submissions and inform regulatory decisions. In addition, this study adds to the body of evidence that e-cigarettes have the potential for substantial reduction in toxicant exposure and associated health risk compared to combustible cigarettes.