TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 033

A quicker method for the analysis of ammonia in e-cigarette aerosols and e-liquids by ion chromatography

ZHU J.; MOORE B.; HEREDIA A.
ITG Brands, Greensboro, NC, USA

Ammonia has been routinely tested for cigarette smoke for a number of years. Common methods employed are based on ion chromatography using cation exchange columns such as Dionex IonPac CS12 and CS16 columns. These two columns provide good separation of the ammonium peak from the proceeding sodium peak. However, the run times including equilibrating time typically exceed well over 20 minutes because of the high retention of ammonium in these columns. Herein we wish to present a quicker and robust method utilizing Dionex CS18 column with run time of 13 minutes (including equilibrating time) that still provides good separation of ammonium peak from sodium peak. The method LOQ is 0.16 ug/puff, with no quantifiable ammonia determined in the e-cigarette sample matrices we have analyzed. A Dionex ICS 5000 ion chromatography system has been utilized for the method. The new method has a calibration range of 0.1 to 2 ug/mL for ammonia and has been validated with good recoveries on e-cigarette aerosols and e-liquids.