Skip to main content
TSRC, Tob. Sci. Res. Conf., 2023, 76, abstr. 37

A randomized, single blinded, cross‑over study to evaluate the pharmacokinetic profiles of e‑cigarettes with nicotine salt formulations in UK adults who use e-cigarettes

TAKESHIGE Y.
JT International, Geneva, Switzerland

When an organic acid combines with a freebase nicotine, it forms a nicotine salt. Recently e-liquids marketed as containing nicotine salts have become popular and it appears that nicotine in salts form can provide a sensorial experience that some adult consumers perceive as more enjoyable and satisfying versus freebase nicotine e-liquids.

Here, we evaluated nicotine pharmacokinetic (PK) profiles and subjective effects following single and multiple ad libitum use of an e-cigarette (eDNC3) with two e-liquid pods, one with and one without organic acid. A randomized, single blinded, cross-over study was conducted in 20 healthy UK adults who use e-cigarettes.

Results showed that the Cmax of plasma nicotine was approximately 53% greater following single ad libitum use and 58% greater following multiple ad libitum use of eDNC3 with e-liquids containing nicotine salts than freebase nicotine, while AUC was approximately 20% greater following single ad libitum use of eDNC3 with e-liquids containing nicotine salts than freebase nicotine. The differences in these PK parameters (Cmax-single, Cmax-multiple and AUC) between the eDNC3 e-liquids with nicotine salts versus freebase nicotine were associated with an increase in the consumed amount of e-liquid corresponding to nicotine consumption. No notable differences were observed between the eDNC3 e-liquids with nicotine salts versus freebase nicotine for any of the subjective effects measured in this study and there were no marked changes or clinically significant findings in the safety data obtained.

These results indicate that use of e-liquid with nicotine salt formulations, made by adding organic acid, leads to an increase in nicotine uptake compared to freebase nicotine e-liquid, and these differences may be explained by increased consumption of e-liquid.