Search Results

24 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 44

    Lung biomarkers of harm/effect for tobacco regulatory research: opportunities and challenges – a literature review

    MAKENA P.(1); EDMISTON J.(2); BEATTIE E.(3); MASON E.(4); McEWAN M.(5); PRASAD K.(5)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Altria Client Services LLC, Richmond, VA, U.S.A.; (3) Cliantha Research Limited, Canada; (4) Imperial Brands PLC, Bristol, U.K.; (5) British American Tobacco (Investments) Limited, Southampton, U.K.
    Biomarkers of potential harm (BoPH) are indicators of biological perturbations in response to smoking, which may contribute to smoking-related disease. In this review, a project of the CORESTA Biomarkers Sub-Group, we critically assessed the available ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 54

    Clinical biomarkers of compliance for use in potentially reduced-risk product switching studies

    McEWAN M.(1); GALE N.(1); HARDIE G.(1); SCHERER M.(2); PLUYM N.(2); EBAJEMITO J.K.(1); CAMACHO O.M.(1); GRIFFITHS A.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, Research and Development, Southampton, U.K.; (2) ABF GmbH, Planegg, Germany
    Preclinical assessments and clinical studies have shown significant reductions in toxicants in tobacco heating product (THP) aerosols compared to smoke from conventional cigarettes. Further studies to assess if these toxicant reductions translate to ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 53

    Nicotine kinetics and subjective effects of two tobacco heating products compared to cigarettes and a nicotine replacement therapy

    HARDIE G.; GALE N.; McEWAN M.; EBAJEMITO J.K.; MURPHY J.; PROCTOR C.J.
    British American Tobacco (Investments) Limited, Research and Development, Southampton, U.K.
    Recently, clinical studies have shown reductions in exposure to tobacco smoke toxicants when smokers of conventional cigarettes switch to a tobacco heating product (THP). Studies on nicotine pharmacokinetics (PK) and subjective effects of potentially ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups (Workshop), STW 08

    Biomarker qualification using adverse outcome pathways (AOPs)

    McEWAN M.; LOWE F.; GACA M.; HARDIE G.; MURPHY J.; PROCTOR C.J.
    British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    Smoking is a leading cause of numerous human disorders including pulmonary disease, cardiovascular disease and cancer. Disease development is primarily caused by years of exposure to cigarette smoke constituents, many of which are known toxicants. ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 17

    A clinical study investigating changes in exposure to cigarette smoke chemicals in U.K. smokers who switch to using a tobacco heating product for a five-day period

    McEWAN M.(1); EBAJEMITO J.K.(1); GALE N.(1); ELDRIDGE A.(1); CAMACHO O.M.(1); MURPHY J.(1); HARDIE G.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) Celerion Inc., Lincoln, NE, U.S.A.
    Smoking is a leading cause of numerous diseases, particularly lung cancer, chronic obstructive pulmonary disease and cardiovascular diseases. Consequently, there is a recognized need to provide smokers with alternative nicotine-delivery devices that have ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 55

    A randomised, controlled study to evaluate the effects of switching from cigarette smoking to using tobacco heating products on health effect indicators in healthy subjects

    HARDIE G.; NEWLAND N.; McEWAN M.; EBAJEMITO J.K.; GALE N.; CAMACHO O.M.; MURPHY J.; PROCTOR C.J.
    British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    Preclinical assessments and 5-day exposure clinical studies have shown that toxicant emissions are lower in tobacco heating products (THPs) compared to conventional cigarettes. However, it is unclear if these reductions are sustained and if they translate ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 25

    A clinical study in Japanese smokers investigating changes in exposure to cigarette smoke chemicals in participants who switch to using a tobacco heating product for a five day period

    GALE N.(1); McEWAN M.(1); ELDRIDGE A.(1); ERRINGTON G.(1); McDERMOTT S.(2); GLEW J.(2); HEDGE A.(2); MURPHY J.(1); PROCTOR C.J.(1); FEARON I.(1)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) Covance Inc., Leeds, U.K.
    Tobacco heating products (THP) are electronic devices that heat tobacco, rather than combusting it. Due to this lack of combustion, significantly fewer toxicants are formed but nicotine is still released into the inhaled aerosol. Clinical studies ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 28 (also presented at TSRC 2017)

    Nicotine pharmacokinetics of electronic cigarettes: experimental data and a review of the literature

    FEARON I.M.(1); ELDRIDGE A.(1); GALE N.(1); McEWAN M.(1); NELSON P.(2); ROUND E.(2); STILES M.(2)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) RAI Services Co., Winston-Salem, NC, U.S.A.
    E-cigarettes are battery-powered electronic devices from which users can inhale nicotine following its aerosolisation from a heated liquid solution. Some regulators and public health bodies consider e-cigarettes as potentially playing a major role in ...
  9. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 088 (also presented at CORESTA SSPT2017)

    Nicotine pharmacokinetics of electronic cigarettes: experimental data and a review of the literature

    FEARON I.M.(1); ELDRIDGE A.(1); GALE N.(1); McEWAN M.(1); NELSON P.(2); ROUND E.(2); STILES M.(2)
    (1) British American Tobacco (Investments) Limited, Southampton, UK; (2) RAI Services Company, Winston-Salem, NC, USA
    E-cigarettes are battery-powered electronic devices from which users can inhale nicotine following its aerosolisation from a heated liquid solution. Some regulators and public health bodies consider e-cigarettes as potentially playing a major role in ...
  10. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 106

    A study to examine changes in exposure to cigarette smoke chemicals when a smoker switches to using a tobacco heating product. Part I: study design

    GALE N.(1); McEWAN M.(1); ELDRIDGE A.(1); CAMACHO O.M.(1); McAUGHEY J.(1); MURPHY J.(1); LIU C.(1); PROCTOR C.J.(1); FEARON I.M.(1); SHERWOOD N.(2); BOWEN E.(3); McDERMOTT S.(3); HOLMES E.(3)
    (1) British American Tobacco (Investments) Ltd, Southampton, UK; (2) Neil Sherwood Consulting, Commugny, Switzerland; (3) Covance, Leeds, UK
    A tobacco heating product (THP), glo™, which heats rather than combusts tobacco and produces significantly reduced machine yields of chemical toxicants compared to combustible cigarettes, was assessed in this study. Biomarker of exposure (BoE) studies are ...