Search Results

21 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups (Workshop), STW 08

    Biomarker qualification using adverse outcome pathways (AOPs)

    McEWAN M.; LOWE F.; GACA M.; HARDIE G.; MURPHY J.; PROCTOR C.J.
    British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    Smoking is a leading cause of numerous human disorders including pulmonary disease, cardiovascular disease and cancer. Disease development is primarily caused by years of exposure to cigarette smoke constituents, many of which are known toxicants. ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 17

    A clinical study investigating changes in exposure to cigarette smoke chemicals in U.K. smokers who switch to using a tobacco heating product for a five-day period

    McEWAN M.(1); EBAJEMITO J.K.(1); GALE N.(1); ELDRIDGE A.(1); CAMACHO O.M.(1); MURPHY J.(1); HARDIE G.(1); PROCTOR C.J.(1)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) Celerion Inc., Lincoln, NE, U.S.A.
    Smoking is a leading cause of numerous diseases, particularly lung cancer, chronic obstructive pulmonary disease and cardiovascular diseases. Consequently, there is a recognized need to provide smokers with alternative nicotine-delivery devices that have ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 55

    A randomised, controlled study to evaluate the effects of switching from cigarette smoking to using tobacco heating products on health effect indicators in healthy subjects

    HARDIE G.; NEWLAND N.; McEWAN M.; EBAJEMITO J.K.; GALE N.; CAMACHO O.M.; MURPHY J.; PROCTOR C.J.
    British American Tobacco (Investments) Limited, R&D, Southampton, U.K.
    Preclinical assessments and 5-day exposure clinical studies have shown that toxicant emissions are lower in tobacco heating products (THPs) compared to conventional cigarettes. However, it is unclear if these reductions are sustained and if they translate ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 25

    A clinical study in Japanese smokers investigating changes in exposure to cigarette smoke chemicals in participants who switch to using a tobacco heating product for a five day period

    GALE N.(1); McEWAN M.(1); ELDRIDGE A.(1); ERRINGTON G.(1); McDERMOTT S.(2); GLEW J.(2); HEDGE A.(2); MURPHY J.(1); PROCTOR C.J.(1); FEARON I.(1)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) Covance Inc., Leeds, U.K.
    Tobacco heating products (THP) are electronic devices that heat tobacco, rather than combusting it. Due to this lack of combustion, significantly fewer toxicants are formed but nicotine is still released into the inhaled aerosol. Clinical studies ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 28 (also presented at TSRC 2017)

    Nicotine pharmacokinetics of electronic cigarettes: experimental data and a review of the literature

    FEARON I.M.(1); ELDRIDGE A.(1); GALE N.(1); McEWAN M.(1); NELSON P.(2); ROUND E.(2); STILES M.(2)
    (1) British American Tobacco (Investments) Limited, R&D, Southampton, U.K.; (2) RAI Services Co., Winston-Salem, NC, U.S.A.
    E-cigarettes are battery-powered electronic devices from which users can inhale nicotine following its aerosolisation from a heated liquid solution. Some regulators and public health bodies consider e-cigarettes as potentially playing a major role in ...
  6. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 088 (also presented at CORESTA SSPT2017)

    Nicotine pharmacokinetics of electronic cigarettes: experimental data and a review of the literature

    FEARON I.M.(1); ELDRIDGE A.(1); GALE N.(1); McEWAN M.(1); NELSON P.(2); ROUND E.(2); STILES M.(2)
    (1) British American Tobacco (Investments) Limited, Southampton, UK; (2) RAI Services Company, Winston-Salem, NC, USA
    E-cigarettes are battery-powered electronic devices from which users can inhale nicotine following its aerosolisation from a heated liquid solution. Some regulators and public health bodies consider e-cigarettes as potentially playing a major role in ...
  7. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 106

    A study to examine changes in exposure to cigarette smoke chemicals when a smoker switches to using a tobacco heating product. Part I: study design

    GALE N.(1); McEWAN M.(1); ELDRIDGE A.(1); CAMACHO O.M.(1); McAUGHEY J.(1); MURPHY J.(1); LIU C.(1); PROCTOR C.J.(1); FEARON I.M.(1); SHERWOOD N.(2); BOWEN E.(3); McDERMOTT S.(3); HOLMES E.(3)
    (1) British American Tobacco (Investments) Ltd, Southampton, UK; (2) Neil Sherwood Consulting, Commugny, Switzerland; (3) Covance, Leeds, UK
    A tobacco heating product (THP), glo™, which heats rather than combusts tobacco and produces significantly reduced machine yields of chemical toxicants compared to combustible cigarettes, was assessed in this study. Biomarker of exposure (BoE) studies are ...
  8. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 107

    A study to examine changes in exposure to cigarette smoke chemicals when a smoker switches to using a tobacco heating product. Part II: study findings

    GALE N.(1); ELDRIDGE A.(1); McEWAN M.(1); ERRINGTON G.(1); MURPHY J.(1); PROCTOR C.J.(1); FEARON I.M.(1); McDERMOTT S.(2); GLEW J.(2); HEDGE A.(2)
    (1) British American Tobacco (Investments) Ltd, Southampton, UK; (2) Covance, Leeds, U.K.
    A tobacco heating product (THP), glo™, which heats rather than combusts tobacco and produces significantly reduced machine yields of chemical toxicants compared to combustible cigarettes, was assessed in this study. Biomarker of exposure (BoE) studies are ...
  9. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 33

    Nicotine delivery from e-cigarettes Part 1: study designs for two pharmacokinetic studies

    FEARON I.M.(1); ELDRIDGE A.(1); GALE N.(1); SHEPPERD C.J.(1); McEWAN M.(1); CAMACHO O.M.(1); MAVROPOULOU E.(1); NIDES M.(2); McADAM K.(1); PROCTOR C.(1)
    (1) British American Tobacco (Investments) Limited, Southampton, UK; (2) Los Angeles Clinical Trials, Burbank, CA, USA
    Nicotine pharmacokinetic (PK) studies are an important tool in developing our understanding of actual nicotine delivery into the body from electronic cigarettes and other nicotine-containing products. Furthermore, data from such studies may potentially be ...
  10. TSRC, Tob. Sci. Res. Conf., 2016, 70, abstr. 34

    Nicotine delivery from e-cigarettes Part 2: data and learnings from two pharmacokinetic studies

    FEARON I.M.(1); ELDRIDGE A.(1); GALE N.(1); SHEPPERD C.J.(1); McEWAN M.(1); CAMACHO O.M.(1); MAVROPOULOU E.(1); NIDES M.(2); McADAM K.(1); PROCTOR C.(1)
    (1) British American Tobacco (Investments) Limited, Southampton, UK; (2) Los Angeles Clinical Trials, Burbank, CA, USA
    Nicotine pharmacokinetic (PK) studies are an important tool in developing our understanding of actual nicotine delivery into the body from electronic cigarettes and other nicotine-containing products. Furthermore, data from such studies may potentially be ...