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25 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 45

    Meta-analysis of two biomarkers of exposure of tobacco products

    AYALA-FIERRO F.(1); ELAMIN A.(2); FROST-PINEDA K.(3); JIN T.(3); PRASAD G.L.(3); SARKAR M.(4); SCHMIDT E.(3); VERRON T.(5)
    (1) ITG Brands LLC, Greensboro, NC, U.S.A.; (2) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (3) RAI Services Company, Winston-Salem, NC, U.S.A.; (4) Altria Client Services LLC, Richmond, VA, U.S.A.; (5) SEITA - Imperial Brands, Paris, France
    In the context of tobacco products, broadly two types of biomarkers exist, biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH). BoE measure exposure to tobacco constituents, e.g. carbon monoxide (CO) and nicotine equivalents (NEQs). The ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 55

    An open-label, parallel-group, controlled study to evaluate changes in biomarkers of cigarette smoke exposure and biomarkers of potential harm in adult smokers who completely switch to using e-vapor products for 24 weeks

    EDMISTON J.; OLIVERI D.; LIANG Q.; SARKAR M.
    Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    The purpose of this study was to characterize biomarkers of exposure (BoE) to select harmful or potentially harmful components (HPHCs) and biomarkers of potential harm (BoPH) in adult smokers (AS) who switched to exclusive use of e-vapor products (EVPs) ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 08

    Modeling the impact of a tobacco product with a modified risk claim on population health: the role of sensitivity analyses

    MUHAMMAD-KAH R.; PITHAWALLA Y.B.; BLACK R.; WEI L.; HANNEL T.; SARKAR M.
    Altria Client Services LLC, Richmond, VA 23219, U.S.A.
    Computational models can be used to assess the population health impact of a modified risk claim on a tobacco product, while taking into account tobacco users and non-tobacco users. We present here a case study of a smokeless tobacco (ST) product with a ...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 043

    An open-label, randomized, parallel-group, controlled study to evaluate changes in biomarkers of cigarette smoke exposure and biomarkers of potential harm in adult smokers who completely switch to using e-vapor products for 12 weeks

    EDMISTON J.; OLIVERI D.; LIANG QIWEI; SARKAR M.
    Altria Client Services, Richmond, VA USA
    The purpose of this study was to characterize biomarkers of exposure (BOE) to select HPHCs and biomarkers of potential harm (BOPH) in adult smokers (AS) who switched to exclusive use of e-vapor products (EVPs) for 12 weeks. Method: Generally healthy AS (N ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups (Workshop), STW 05

    The role of biomarkers in assessing individual health risks of tobacco products

    SARKAR M.
    Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    Assessment of the individual health risk of a modified risk tobacco product (MRTP) is an important component of the regulatory decision-making process for granting authorization of such products. Cigarette smoke contains a mixture of thousands of ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 14

    Characterization of nicotine pharmacokinetic profile and subjective effect measures for e-vapor products relative to cigarette and nicotine gum

    LIU Jianmin; LIANG Qiwei; WANG Jingzhu; VANSICKEL A.; GOGOVA M.; ZHAO Yuxi; SARKAR M.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    The rate and extent of nicotine uptake along with subjective measures are commonly used to assess dependence potential of new tobacco products. We conducted two clinical studies with ~70 adult smokers (AS) each to evaluate the dependence potential of ...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 27

    Characterization of puff topography of adult conventional cigarette smokers and exclusive e-vapor users during ad libitum use of MarkTen® e-vapor products

    EDMISTON J.S.; VANSICKEL A.; LIANG Qiwei; GOGOVA M.; SARKAR M.; KARLES G.D.
    Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    Introduction: We characterized puff topography in adult exclusive e vapor users [EV] and cigarette smokers [CS] on MarkTen ® e vapor products: (3 non-menthol [2.5-4.0 % nicotine] and 3 menthol [3.5-4.0 % nicotine]). Method: CS (n=61, 52 % male) and EV (n ...
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 37

    Assessing the population health impact of authorizing the marketing of a smokeless tobacco product with a proposed modified risk claim

    MUHAMMAD-KAH R.(1); PITHAWALLA Y.B.(1); JONES M.(1); WEI L.(1); BRYAN T.(1); BLACK R.(1); BOONE E.(2); SARKAR M.(1)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Virginia Commonwealth University, Richmond, VA, U.S.A.
    Computational models can be used to predict population effects following the market authorization of a tobacco product with a modified risk claim. Using best modeling practices we developed and validated a population model. Since moist smokeless tobacco ...
  9. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 61

    Novel biomarkers to characterize exposure to aldehydes from e-vapor products based on stable-isotope constituents

    LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.S.(2); PLUYM N.(1)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E vapor products (EVP) are an emerging category of non-combustible tobacco products that hold the promise of harm reduction for users of combustible products. Degradation products such as aldehydes have received much attention lately, however human ...
  10. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 40

    Analytical methods for the determination of aldehydes in e-vapor aerosol and cigarette smoke and their urinary biomarkers of exposure

    LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.S.(2); PLUYM N.(1)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services, Center for Research and Technology, Richmond, VA, U.S.A.
    Potential exposure to aldehydes, such as acrolein, formaldehyde or acetaldehyde, formed due to thermal degradation of the e-liquid constituents propylene glycol (PG) and glycerol (G) during the consumption of e-vapor products (EVPs), have received much ...