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21 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups (Workshop), STW 05

    The role of biomarkers in assessing individual health risks of tobacco products

    SARKAR M.
    Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    Assessment of the individual health risk of a modified risk tobacco product (MRTP) is an important component of the regulatory decision-making process for granting authorization of such products. Cigarette smoke contains a mixture of thousands of ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 14

    Characterization of nicotine pharmacokinetic profile and subjective effect measures for e-vapor products relative to cigarette and nicotine gum

    LIU Jianmin; LIANG Qiwei; WANG Jingzhu; VANSICKEL A.; GOGOVA M.; ZHAO Yuxi; SARKAR M.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    The rate and extent of nicotine uptake along with subjective measures are commonly used to assess dependence potential of new tobacco products. We conducted two clinical studies with ~70 adult smokers (AS) each to evaluate the dependence potential of ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 27

    Characterization of puff topography of adult conventional cigarette smokers and exclusive e-vapor users during ad libitum use of MarkTen® e-vapor products

    EDMISTON J.S.; VANSICKEL A.; LIANG Qiwei; GOGOVA M.; SARKAR M.; KARLES G.D.
    Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    Introduction: We characterized puff topography in adult exclusive e vapor users [EV] and cigarette smokers [CS] on MarkTen ® e vapor products: (3 non-menthol [2.5-4.0 % nicotine] and 3 menthol [3.5-4.0 % nicotine]). Method: CS (n=61, 52 % male) and EV (n ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 37

    Assessing the population health impact of authorizing the marketing of a smokeless tobacco product with a proposed modified risk claim

    MUHAMMAD-KAH R.(1); PITHAWALLA Y.B.(1); JONES M.(1); WEI L.(1); BRYAN T.(1); BLACK R.(1); BOONE E.(2); SARKAR M.(1)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Virginia Commonwealth University, Richmond, VA, U.S.A.
    Computational models can be used to predict population effects following the market authorization of a tobacco product with a modified risk claim. Using best modeling practices we developed and validated a population model. Since moist smokeless tobacco ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 61

    Novel biomarkers to characterize exposure to aldehydes from e-vapor products based on stable-isotope constituents

    LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.S.(2); PLUYM N.(1)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E vapor products (EVP) are an emerging category of non-combustible tobacco products that hold the promise of harm reduction for users of combustible products. Degradation products such as aldehydes have received much attention lately, however human ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 40

    Analytical methods for the determination of aldehydes in e-vapor aerosol and cigarette smoke and their urinary biomarkers of exposure

    LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.S.(2); PLUYM N.(1)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services, Center for Research and Technology, Richmond, VA, U.S.A.
    Potential exposure to aldehydes, such as acrolein, formaldehyde or acetaldehyde, formed due to thermal degradation of the e-liquid constituents propylene glycol (PG) and glycerol (G) during the consumption of e-vapor products (EVPs), have received much ...
  7. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 23

    Biomarkers of exposure specific to e-vapor products based on stable-isotope labelled ingredients – clinical study design

    SCHERER M.(1); LANDMESSER A.(1); PLUYM N.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.(2)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E-vapor products (EVPs) are becoming an accepted alternative to conventional cigarettes among smokers. Despite the increasing popularity of EVPs, little information exists on the fate of the main ingredients glycerol (G), propylene glycol (PG) and ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, ST 24

    Biomarkers of exposure specific to e-vapour products based on stable-isotope labelled ingredients – results

    PLUYM N.(1); LANDMESSER A.(1); SCHERER M.(1); SCHERER G.(1); SARKAR M.(2); EDMISTON J.(2)
    (1) ABF Analytisch-Biologisches Forschungslabor GmbH, Planegg, Germany; (2) Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    E-vapor products (EVPs) consumption has steadily increased worldwide over the past decade. Ever since their introduction, there have been discussions about the potential health risks of EVPs in the scientific and public health community. These discussions ...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 05 (also presented at TSRC 2017)

    Differences in plasma nicotine pharmacokinetic profiles for various e-vapor products used by adult smokers under ad libitum vs. controlled use conditions

    LIU J.; LIANG Q.; GOGOVA M.; ZHAO Y.; SARKAR M.
    Altria Client Services LLC, Center for Research and Technology, Richmond, VA, U.S.A.
    Plasma nicotine pharmacokinetic (PK) profiles are often used to characterize nicotine exposure from e-vapor products (EVP). The purpose of this analysis was to determine whether PK profiles are different when adult smokers (AS) use EVPs under ad libitum ...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2017, Kitzbühel, STPOST 42

    Identification of candidate biomarkers of tobacco related diseases through gene/disease associations

    EDMISTON J.(1); JESSEN W.(2); GOMATHINAYAGAM S.(3); REES W.(1); SARKAR M.(1)
    (1) Altria Client Services LLC, Center for Research and Technology, Richmond, VA 23219, U.S.A.; (2) Laboratory Corporation of America, Greenfield, IN, U.S.A.; (3) Covance Greenfield Laboratories, Greenfield, IN, U.S.A.
    Biomarkers can be useful tools in measuring the biological effects of tobacco product use. Although there is a small group of biomarkers that are typically used to assess the biological effect of tobacco use, there are few publications summarizing recent ...