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55 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 45

    Meta-analysis of two biomarkers of exposure of tobacco products

    AYALA-FIERRO F.(1); ELAMIN A.(2); FROST-PINEDA K.(3); JIN T.(3); PRASAD G.L.(3); SARKAR M.(4); SCHMIDT E.(3); VERRON T.(5)
    (1) ITG Brands LLC, Greensboro, NC, U.S.A.; (2) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (3) RAI Services Company, Winston-Salem, NC, U.S.A.; (4) Altria Client Services LLC, Richmond, VA, U.S.A.; (5) SEITA - Imperial Brands, Paris, France
    In the context of tobacco products, broadly two types of biomarkers exist, biomarkers of exposure (BoE) and biomarkers of potential harm (BoPH). BoE measure exposure to tobacco constituents, e.g. carbon monoxide (CO) and nicotine equivalents (NEQs). The ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 50 (also presented at TSRC 2019)

    Altered lung barrier function is a physiologically-relevant biomarker of potential harm

    MAKENA P.; BAXTER-WRIGHT S.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, U.S.A.
    Cigarette smoking is a major risk factor for diseases including cardiovascular disease, lung cancer, and chronic obstructive pulmonary disease (COPD). One of the key functions of lung epithelial cells is to serve as a physical barrier against insults ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 51

    Structural investigation of the tobacco specific urinary biomarker iPX

    SCHMIDT E.; PRASAD G.L.
    RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.
    Biomarkers of potential harm (BoPH) are tools to assess biological and pathophysiological effects associated with chronic tobacco product use, such as oxidative stress. Isoprostanes are widely recognized as BoPH for assessing endogenous oxidative stress. ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 52 (also presented at TSRC 2019)

    A blood-based smoking-related gene expression signature using a machine learning approach

    LIU G.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, U.S.A.
    Smoking is a leading risk factor in the onset of multiple forms of cancer, chronic obstructive pulmonary disease, and cardiovascular disease. At present, there is a limited understanding by which changes in gene expression profiles in blood or other ...
  5. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 015

    Levels of endothelial progenitor cells (EPCs) in smokers and moist snuff consumers

    ARIMILLI S.(1); CHEN P.(2); PRASAD G.L.(2)
    (1) Eurofins Professional Scientific Services, Winston Salem, NC, USA; (2) RAI Services Company, Winston Salem, NC, USA
    Endothelial progenitor cells (EPCs) are a key cell type present in circulation and are reported to play a role in the development of cardiovascular diseases. EPCs are derived from the bone marrow and mediate the differentiation, regeneration and ...
  6. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 030

    Identification of predictive clinical biomarkers for developing chronic obstructive pulmonary disease using real world evidence data

    LIU GANG M.; MAKENA P.; HONG Kyung Soo; SCOTT E.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, USA
    Identification of predictive biomarkers and quantification of individual risk for developing smoking-associated diseases such as Chronic Obstructive Pulmonary Disease (COPD) aids in evaluating and predicting the health effects from tobacco products. This ...
  7. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 048 (also presented at CORESTA SSPT2019)

    A blood-based smoking-related gene expression signature using a machine learning approach

    LIU GANG M.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, USA
    Smoking is a leading risk factor in the onset of multiple forms of cancer, chronic obstructive pulmonary disease, and cardiovascular disease. At present, there is a limited understanding by which changes in gene expression profiles in blood or other ...
  8. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 084 (also presented at CORESTA SSPT2019)

    Altered lung barrier function is a physiologically-relevant biomarker of potential harm

    MAKENA P.; BAXTER-WRIGHT S.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, USA
    Cigarette smoking is a major risk factor for diseases including cardiovascular disease, lung cancer, and COPD. One of the key functions of lung epithelial cells is to serve as a physical barrier against insults including cigarette smoke. Chronic smoking ...
  9. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 090

    Differential regulation of ion channel function from exposures to cigarette smoke and ENDs preparations

    RAYNER R.E.(1); MAKENA P.(2); PRASAD G.L.(2); CORMET-BOYAKA E.(1)
    (1) The Ohio State University, Columbus, OH, USA; (2) RAI Services Company, Winston Salem, NC, USA
    Cigarette smoking is known to disrupt the normal mucociliary function of the lungs, whereas the effect of Electronic Nicotine Delivery Systems (ENDS) is incompletely understood. This study aimed to compare the effects of acute exposure of primary normal ...
  10. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 59

    An inter-laboratory comparison study focused on the determination of total NNAL in human urine

    NEWLAND K.(1); SCHERER M.(2); HECHT S.S.(3); TROUDE V.(4); PRASAD G.L.(5)
    (1) Celerion Inc., Lincoln, NE, U.S.A.; (2) ABF GmbH, Planegg, Germany; (3) University of Minnesota Cancer Center, Minneapolis, MN, U.S.A.; (4) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (5) RAI Services Company, Winston-Salem, NC, U.S.A.
    In an ongoing effort to fulfil the second objective of the CORESTA Biomarker Sub-Group, periodic inter-laboratory comparison studies have been performed to evaluate the consistency of the quantitation for various harmful or potentially harmful exposure ...