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46 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 59

    An inter-laboratory comparison study focused on the determination of total NNAL in human urine

    NEWLAND K.(1); SCHERER M.(2); HECHT S.S.(3); TROUDE V.(4); PRASAD G.L.(5)
    (1) Celerion Inc., Lincoln, NE, U.S.A.; (2) ABF GmbH, Planegg, Germany; (3) University of Minnesota Cancer Center, Minneapolis, MN, U.S.A.; (4) Reemtsma Cigarettenfabriken GmbH, Imperial Brands plc, Hamburg, Germany; (5) RAI Services Company, Winston-Salem, NC, U.S.A.
    In an ongoing effort to fulfil the second objective of the CORESTA Biomarker Sub-Group, periodic inter-laboratory comparison studies have been performed to evaluate the consistency of the quantitation for various harmful or potentially harmful exposure ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 62

    Immune functions are perturbed to a greater extent with smoking rather than moist snuff use

    TRAN Q.T.(1); ARIMILLI S.(2); JOHNSON E.(3); LIU Gang(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Wake Forest University, School of Medicine, Department of Microbiology and Immunology, Winston-Salem, NC, U.S.A.; (3) University of North Carolina, Department of Mathematics and Statistics, Greensboro, NC, U.S.A.
    Cigarette smoking is a major risk factor for lung cancer, chronic obstructive pulmonary disease, and cardiovascular disease (CVD). Existing epidemiological data suggest moist snuff consumption is generally associated with reduced health risks relative to ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 63

    Metabolomics analysis identified reduced levels of oxidative stress and improved vitamin metabolism in smokers switching to an electronic nicotine delivery system (ENDS)

    LIU Gang; NASRIN N.; TRAN Q.T.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, U.S.A.
    Switching to non-combustible tobacco products presents an opportunity for cigarette smokers to potentially reduce the harm associated with smoking. Electronic nicotine delivery systems (ENDS) are one type of non-combustible tobacco product that hold ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 62

    Nasal mucociliary clearance is a physiologically-relevant biomarker of tobacco effect/potential harm

    MAKENA P.; BAXTER S.; JONES B.A.; EVANS E.H.; CHEN P.; KREBS H.; GILL R.K.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, U.S.A.
    Chronic cigarette smoking increases the risk of several diseases including chronic obstructive pulmonary disease (COPD). The pathophysiology of COPD can be attributed to multiple components: mucociliary dysfunction, airway inflammation and structural ...
  5. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 018

    Development of a small airway lung model using microfluidic lung-on-a-chip device

    MAKENA P.(1); PRASAD G.L.(1); GORDON D.(2); HAITHCOCK D.(2); PRABHAKARPANDIAN B.(2); PANT K.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) SynVivo Inc., Huntsville, AL, USA
    Current in vitro models of small airway lung, which have primarily been developed on a transwell membrane with epithelial cells cultured at air liquid interface (ALI), lack certain elements of the in vivo physiology such as fluidic shear and endothelial ...
  6. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 019

    Microfluidic small airway lung model for toxicity screening of tobacco products

    MAKENA P.(1); PRASAD G.L.(1); GORDON D.(2); HAITHCOCK D.(2); PRABHAKARPANDIAN B.(2); PANT K.(2)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) SynVivo Inc., Huntsville, AL, USA
    Physiologically relevant in vitro lung models are valuable tools to accurately assess the cytotoxicity of inhaled toxicants. Epithelial cells cultured in transwells do not accurately represent the cellular architecture, physiology, and fluidic shear ...
  7. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 026

    Benchmark dose modeling of genomic data to assess the functional effects of cigarette smoke exposure on peripheral blood mononuclear cells

    LIU Gang; TRAN Q.T.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, USA
    Benchmark dose (BMD) modeling of toxicogenomics data has gained interest from regulatory agencies for chemical risk and toxicity assessment. To date, limited studies have used this tool for assessing toxicological effects associated with the use of ...
  8. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 066

    Distinct gene expression changes in peripheral blood mononuclear cells exposed to combustible versus non-combustible tobacco product preparations

    TRAN N.Q.(1); ARIMILLI S.(2); MADAHIAN B.(3); HOMAYOUNI R.(3); PRASAD G.L.(1)
    (1) RAI Services, Winston-Salem, NC, USA; (2) Wake Forest University, Winston-Salem, NC, USA; (3) Quire Inc., Memphis, TN, USA
    Cigarette smoking exerts diverse physiological effects including immune suppression. Existing epidemiological data show that consumption of smokeless tobacco products, such as moist snuff, is less harmful relative to smoking. We previously demonstrated ...
  9. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 074

    Urinary leukotriene E4 and 2,3-dinor thromboxane B2 are potential biomarkers of effect for tobacco product evaluations

    MAKENA P.; LIU Gang; NOURI N.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, USA
    Adverse health outcomes from cigarette smoking generally take several decades to develop. Physiologically-relevant biomarkers of effect (BioEff), such as FEV1, typically require sustained smoking abstinence over several months to detect a significant ...
  10. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 080

    Differential gene expression and functional responses in peripheral blood mononuclear cells pretreated with combustible and non-combustible tobacco products

    TRAN Q.T.(1); ARIMILLI S.(2); LIU Gang(1); MAKENA P.(1); PRASAD G.L.(1)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Wake Forest School of Medicine, Winston-Salem, NC, USA
    Chronic smoking is known to alter immune responses, which compromises tumor surveillance and host defense against microbial infections. We previously showed that smokers (SMK) exhibit distinct peripheral blood mononuclear cell (PBMC) gene expression ...