Search Results

27 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 05 (also presented at TSRC 2018)

    Structure-activity relationships of propylene glycol, glycerin, and select analogs for carbonyl thermal degradation products

    MELVIN M.S.; BALLENTINE R.M.; GARDNER W.P.; McKINNEY W.J.; PITHAWALLA Y.B.; SMITH D.C.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In 2016, the Food and Drug Administration (FDA) issued draft Guidance to Industry regarding the submission of Premarket Tobacco Applications for electronic nicotine delivery systems (ENDS). In this draft guidance, the FDA recommends reporting several ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 07 (also presented at TSRC 2018)

    Evaluation of the formaldehyde hemiacetals and acetals relevant to electronic cigarettes

    JIN Xiaohong C.; AVERY K.C.; BALLENTINE R.M.; GARDNER W.P.; McKINNEY W.J.; MELVIN M.S.; PITHAWALLA Y.B.; SMITH D.C.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In 2016, the Food and Drug Administration (FDA) issued draft Guidance to Industry regarding the submission of Premarket Tobacco Applications for Electronic Nicotine Delivery Systems (ENDS). In this draft guidance, the FDA recommends reporting toxicants in ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 29 (also presented at TSRC 2018)

    Modification of standardized methods for the measurement of nicotine in very low nicotine content cigarettes

    BROWN A.P.(1); LIU Hui(2); MANSON K.(2); MELVIN M.S.(1); PIEROTTI J.(2); PITHAWALLA Y.B.(1); SMITH J.H.(1); STUTT K.(2); WAGNER K.A.(1)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Eurofins Lancaster Professional Scientific Staffing, Richmond, VA, U.S.A.
    In March 2018, the U.S. Food and Drug Administration (FDA) issued an advanced notice of proposed rulemaking (ANPRM) for a nicotine product standard that would limit the amount of nicotine in combusted tobacco products. FDA requested comments regarding ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 37

    Assessing the population health impact of authorizing the marketing of a smokeless tobacco product with a proposed modified risk claim

    MUHAMMAD-KAH R.(1); PITHAWALLA Y.B.(1); JONES M.(1); WEI L.(1); BRYAN T.(1); BLACK R.(1); BOONE E.(2); SARKAR M.(1)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Virginia Commonwealth University, Richmond, VA, U.S.A.
    Computational models can be used to predict population effects following the market authorization of a tobacco product with a modified risk claim. Using best modeling practices we developed and validated a population model. Since moist smokeless tobacco ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 68

    E-cigarette aerosol dynamics in a physical model of the adult human oral/pharyngeal/tracheal cavity

    WANG Qing; CASTRO N.D.; ZHANG Jingjie; LI Weiling; PITHAWALLA Y.B.; OLDHAM M.J.; LIPOWICZ P.; ROSTAMI A.A.
    Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond, VA, U.S.A.
    The objective of this work is to generate experimental data to validate a computational deposition model for e cigarette aerosol. An adult human oral/pharyngeal/tracheal hollow prototype model was generated using a 3D printer from the CT scan of a 28 year ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 28 (also presented at TSRC 2018)

    Non-targeted analysis for differential screening of tobacco samples

    MILLER J.H.; PITHAWALLA Y.B.; DANIELSON T.L.; XU Dongmei
    Altria Client Services LLC, Richmond, VA, U.S.A.
    Non-targeted analysis of samples has broad applications across the food industry and in the evaluation of natural products. For example, this approach has been used by the food industry to evaluate purity and quality of fruit juices, olive oil and tea. ...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 44 (also presented at TSRC 2018)

    Non-targeted analysis using gas chromatography mass spectrometry to evaluate stability of e-vapor products

    SHAH N.; CROSSWHITE M.; NOE M.R.; SUAREZ C.; MILLER J.H.; PITHAWALLA Y.B.; GARDNER W.P.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In the newly regulated landscape of tobacco products there is an increasing need to fully characterize the chemical composition of aerosol in new products. Although aerosol from e-vapor products are considerably less complex than aerosols from heat-not ...
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 57

    Assessing the potential population health impact of market authorization of e-cigarettes in the U.S.

    MUHAMMAD-KAH R.; PITHAWALLA Y.B.; HANNEL T.; WEI L.; BLACK R.; BRYAN T.; GOGOVA M.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    When evaluating a Premarket Tobacco Product Application (PMTA) or Modified Risk Tobacco Product Application (MRTPA), the Food and Drug Administration (FDA) employs a Population Health Standard, which requires evaluation of risk and benefit to the ...
  9. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 59 (also presented at TSRC 2018)

    Quantification of nicotine related impurities in novel, oral tobacco-derived nicotine products

    DANIELSON T.L.; McFARLANE C.B.; NOE M.R.; PITHAWALLA Y.B.; McKINNEY W.J. Jr
    Altria Client Services LLC, Research, Development & Regulatory Sciences, Richmond, VA, U.S.A.
    VERVE ® Discs and Chews are oral, non-dissolvable, tobacco-derived nicotine products. All tobacco products sold in the U.S. are regulated by the FDA and this category of products will ultimately require a market authorization through the premarket tobacco ...
  10. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 60 (also presented at TSRC 2018)

    Evaluation of novel, oral tobacco-derived nicotine products for HPHCs

    DANIELSON T.L.; McFARLANE C.B.; BROWN A.P.; JIN Xiaohong C.; WILKINSON C.T.; PITHAWALLA Y.B.; McKINNEY W.J. Jr
    Altria Client Services LLC, Research, Development & Regulatory Sciences, Richmond, VA, U.S.A.
    In May 2016, the U.S. Food and Drug Administration (FDA) issued a final rule to deem e cigarettes, cigars and all other tobacco products to be subject to the Federal Food, Drug, and Cosmetic Act (the FD&C Act), as amended by the Family Smoking ...