Search Results

30 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 50 (also presented at TSRC 2019)

    In vitro dissolution testing of nicotine release from smokeless tobacco products

    MILLER J.H.; DANIELSON T.L.; ALDEEK F.; PITHAWALLA Y.B.; WILKINSON C.T.; BROWN A.P.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA 23219, U.S.A.
    Developing dissolution testing methods to measure the nicotine release profiles from smokeless tobacco products is valuable for product assessment and for product-to-product comparisons. Furthermore, it can allow for understanding which physical or ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 08

    Modeling the impact of a tobacco product with a modified risk claim on population health: the role of sensitivity analyses

    MUHAMMAD-KAH R.; PITHAWALLA Y.B.; BLACK R.; WEI L.; HANNEL T.; SARKAR M.
    Altria Client Services LLC, Richmond, VA 23219, U.S.A.
    Computational models can be used to assess the population health impact of a modified risk claim on a tobacco product, while taking into account tobacco users and non-tobacco users. We present here a case study of a smokeless tobacco (ST) product with a ...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 098 (also presented at CORESTA SSPT2019)

    In vitro dissolution testing of nicotine release from smokeless tobacco products

    MILLER J.H. IV; DANIELSON T.L.; PITHAWALLA Y.B.; WILKINSON C.T.; BROWN A.P.; WAGNER K.A.
    Altria Client Services, Richmond, VA, USA
    Developing dissolution testing methods to measure the nicotine release profiles from smokeless tobacco products is valuable for product assessment and for product-to-product comparisons. Furthermore, it can allow for understanding which physical or ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 05 (also presented at TSRC 2018)

    Structure-activity relationships of propylene glycol, glycerin, and select analogs for carbonyl thermal degradation products

    MELVIN M.S.; BALLENTINE R.M.; GARDNER W.P.; McKINNEY W.J.; PITHAWALLA Y.B.; SMITH D.C.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In 2016, the Food and Drug Administration (FDA) issued draft Guidance to Industry regarding the submission of Premarket Tobacco Applications for electronic nicotine delivery systems (ENDS). In this draft guidance, the FDA recommends reporting several ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 07 (also presented at TSRC 2018)

    Evaluation of the formaldehyde hemiacetals and acetals relevant to electronic cigarettes

    JIN Xiaohong C.; AVERY K.C.; BALLENTINE R.M.; GARDNER W.P.; McKINNEY W.J.; MELVIN M.S.; PITHAWALLA Y.B.; SMITH D.C.; WAGNER K.A.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In 2016, the Food and Drug Administration (FDA) issued draft Guidance to Industry regarding the submission of Premarket Tobacco Applications for Electronic Nicotine Delivery Systems (ENDS). In this draft guidance, the FDA recommends reporting toxicants in ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 29 (also presented at TSRC 2018)

    Modification of standardized methods for the measurement of nicotine in very low nicotine content cigarettes

    BROWN A.P.(1); LIU Hui(2); MANSON K.(2); MELVIN M.S.(1); PIEROTTI J.(2); PITHAWALLA Y.B.(1); SMITH J.H.(1); STUTT K.(2); WAGNER K.A.(1)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Eurofins Lancaster Professional Scientific Staffing, Richmond, VA, U.S.A.
    In March 2018, the U.S. Food and Drug Administration (FDA) issued an advanced notice of proposed rulemaking (ANPRM) for a nicotine product standard that would limit the amount of nicotine in combusted tobacco products. FDA requested comments regarding ...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 37

    Assessing the population health impact of authorizing the marketing of a smokeless tobacco product with a proposed modified risk claim

    MUHAMMAD-KAH R.(1); PITHAWALLA Y.B.(1); JONES M.(1); WEI L.(1); BRYAN T.(1); BLACK R.(1); BOONE E.(2); SARKAR M.(1)
    (1) Altria Client Services LLC, Richmond, VA, U.S.A.; (2) Virginia Commonwealth University, Richmond, VA, U.S.A.
    Computational models can be used to predict population effects following the market authorization of a tobacco product with a modified risk claim. Using best modeling practices we developed and validated a population model. Since moist smokeless tobacco ...
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 68

    E-cigarette aerosol dynamics in a physical model of the adult human oral/pharyngeal/tracheal cavity

    WANG Qing; CASTRO N.D.; ZHANG Jingjie; LI Weiling; PITHAWALLA Y.B.; OLDHAM M.J.; LIPOWICZ P.; ROSTAMI A.A.
    Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond, VA, U.S.A.
    The objective of this work is to generate experimental data to validate a computational deposition model for e cigarette aerosol. An adult human oral/pharyngeal/tracheal hollow prototype model was generated using a 3D printer from the CT scan of a 28 year ...
  9. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 28 (also presented at TSRC 2018)

    Non-targeted analysis for differential screening of tobacco samples

    MILLER J.H.; PITHAWALLA Y.B.; DANIELSON T.L.; XU Dongmei
    Altria Client Services LLC, Richmond, VA, U.S.A.
    Non-targeted analysis of samples has broad applications across the food industry and in the evaluation of natural products. For example, this approach has been used by the food industry to evaluate purity and quality of fruit juices, olive oil and tea. ...
  10. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 44 (also presented at TSRC 2018)

    Non-targeted analysis using gas chromatography mass spectrometry to evaluate stability of e-vapor products

    SHAH N.; CROSSWHITE M.; NOE M.R.; SUAREZ C.; MILLER J.H.; PITHAWALLA Y.B.; GARDNER W.P.
    Altria Client Services LLC, Richmond, VA, U.S.A.
    In the newly regulated landscape of tobacco products there is an increasing need to fully characterize the chemical composition of aerosol in new products. Although aerosol from e-vapor products are considerably less complex than aerosols from heat-not ...