Search Results

31 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 50 (also presented at TSRC 2019)

    Altered lung barrier function is a physiologically-relevant biomarker of potential harm

    MAKENA P.; BAXTER-WRIGHT S.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, U.S.A.
    Cigarette smoking is a major risk factor for diseases including cardiovascular disease, lung cancer, and chronic obstructive pulmonary disease (COPD). One of the key functions of lung epithelial cells is to serve as a physical barrier against insults ...
  2. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 015

    Levels of endothelial progenitor cells (EPCs) in smokers and moist snuff consumers

    ARIMILLI S.(1); CHEN P.(2); PRASAD G.L.(2)
    (1) Eurofins Professional Scientific Services, Winston Salem, NC, USA; (2) RAI Services Company, Winston Salem, NC, USA
    Endothelial progenitor cells (EPCs) are a key cell type present in circulation and are reported to play a role in the development of cardiovascular diseases. EPCs are derived from the bone marrow and mediate the differentiation, regeneration and ...
  3. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 084 (also presented at CORESTA SSPT2019)

    Altered lung barrier function is a physiologically-relevant biomarker of potential harm

    MAKENA P.; BAXTER-WRIGHT S.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston Salem, NC, USA
    Cigarette smoking is a major risk factor for diseases including cardiovascular disease, lung cancer, and COPD. One of the key functions of lung epithelial cells is to serve as a physical barrier against insults including cigarette smoke. Chronic smoking ...
  4. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 091

    Tobacco-specific nitrosamines in the mainstream smoke of commercial little cigars

    EDWARDS S.H.(1); HASSINK M.(1); TAYLOR K.M.(1); WATSON C.(2); KUKLENYIK P.(2); WANG R.(2); CHEN P.(2); VALENTIN-BLASINI L.(2); KIMBRELL B.(2)
    (1) US Food and Drug Administration (FDA), Silver Spring, MD, USA; (2) Centers for Disease Control and Prevention, Atlanta, GA, USA
    Cigars are among the broad variety of deemed tobacco products that have been less extensively studied and characterized than cigarettes. Small sheet-wrapped cigars, often called little cigars, are a subcategory of cigars that are similar to conventional ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 62

    Nasal mucociliary clearance is a physiologically-relevant biomarker of tobacco effect/potential harm

    MAKENA P.; BAXTER S.; JONES B.A.; EVANS E.H.; CHEN P.; KREBS H.; GILL R.K.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, U.S.A.
    Chronic cigarette smoking increases the risk of several diseases including chronic obstructive pulmonary disease (COPD). The pathophysiology of COPD can be attributed to multiple components: mucociliary dysfunction, airway inflammation and structural ...
  6. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 074

    Urinary leukotriene E4 and 2,3-dinor thromboxane B2 are potential biomarkers of effect for tobacco product evaluations

    MAKENA P.; LIU Gang; NOURI N.; CHEN P.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, USA
    Adverse health outcomes from cigarette smoking generally take several decades to develop. Physiologically-relevant biomarkers of effect (BioEff), such as FEV1, typically require sustained smoking abstinence over several months to detect a significant ...
  7. TSRC, Tob. Sci. Res. Conf., 2015, 69, abstr. 53

    Influence of cigarette filter ventilation on smokers’ mouth level exposure to tar and nicotine: a retrospective meta-analysis of 11 studies in 9 countries

    FEARON I.M.(1); BOWMAN S.A.(2); CARAWAY J.W.(2); CHEN P.(2); NELSON P.R.(2); ASHLEY M.(1); SHEPPERD C.J.(1); ERRINGTON G.(1)
    (1) British American Tobacco (Investments) Limited, Southampton, UK; (2) R.J. Reynolds Tobacco Company, Winston-Salem, NC USA
    Cigarette filter ventilation allows air to be drawn into the mainstream smoke which, when the ventilation is unblocked, dilutes the smoke. When cigarettes are machine-smoked using the Health Canada Intense method, ventilation holes are blocked and this ...
  8. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 81

    Clinical trial to compare smoking cessation rates with Camel SNUS and a nicotine lozenge – Part 1: Study Design

    NELSON P.R.; CHEN P.
    R.J. Reynolds Tobacco Company, Winston-Salem, NC, U.S.A.
    R.J. Reynolds conducted a multicenter clinical trial to compare smoking cessation rates when healthy smokers with the intent to quit were switched to Camel SNUS or a nicotine lozenge. The primary objectives of the study examined whether SNUS was superior ...
  9. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 82

    Clinical trial to compare smoking cessation rates with Camel SNUS and a nicotine lozenge – Part 2: Results

    NELSON P.R.; CHEN P.
    R.J. Reynolds Tobacco Company, Winston-Salem, NC, U.S.A.
    R.J. Reynolds conducted a multicenter clinical trial to compare smoking cessation rates with Camel SNUS, with and without smokeless tobacco health-related background information, and a nicotine lozenge. Cessation was evaluated using Fisher’s exact test ...