Search Results

22 results

  1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 62

    Nasal mucociliary clearance is a physiologically-relevant biomarker of tobacco effect/potential harm

    MAKENA P.; BAXTER S.; JONES B.A.; EVANS E.H.; CHEN P.; KREBS H.; GILL R.K.; PRASAD G.L.
    RAI Services Company, Winston-Salem, NC, U.S.A.
    Chronic cigarette smoking increases the risk of several diseases including chronic obstructive pulmonary disease (COPD). The pathophysiology of COPD can be attributed to multiple components: mucociliary dysfunction, airway inflammation and structural ...
  2. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 057

    Nicotine uptake in naïve, short-term and experienced ends users compared to nicotine uptake in smokers

    HONG J.(KS); JONES B.A.; BAXTER-WRIGHT S.; JIN Tao; CAMPBELL L.
    RAI Services Company, Winston-Salem, NC, USA
    Consensus is growing among researchers and public health organizations, including the National Academies of Science, Engineering and Medicine, and American Cancer Society, on harm reduction from the use of electronic nicotine delivery systems (ENDS) as ...
  3. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 077

    Reduction in urinary and blood biomarkers of tobacco exposure in smokers switched to an electronic nicotine delivery system product

    KANOBE M.; JONES B.A.; CHEN Xiaoming; ECKHARDT S.; DARNELL J.; BROWN B.G.
    RAI Services Company, Winston-Salem, NC, USA
    Electronic nicotine delivery system (ENDS) products have the potential to provide nicotine to tobacco consumers while reducing exposure to combustion-related toxicants. This study evaluated changes in biomarker(s) of exposure (BOE) to combustion-related ...
  4. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 16

    Inflammatory cytokines in tobacco consumers as potential biomarkers of tobacco effect

    PRASAD G.L.; JONES B.A.; CARAWAY J.; BORGERDING F.
    R.J. Reynolds Tobacco Company, R&D Department, Winston-Salem, NC, U.S.A.
    Chronic cigarette smoking causes inflammation and some reports indicate that generally healthy smokers (SMK) exhibit changes in the inflammatory cytokines versus non-smokers. However, it remains to be established whether consumers of non-combustible ...
  5. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, STPOST 17

    Global profiling of metabolites from saliva of tobacco consumers

    PRASAD G.L.(1); JONES B.A.(1); SCHMIDT E.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Company, R&D Department, Winston-Salem, NC, U.S.A.; (2) Metabolon, Durham, NC, U.S.A.
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term health ...
  6. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 17

    Global profiling of metabolites from saliva of tobacco consumers

    PRASAD G.L.(1); JONES B.A.(1); SCHMIDT E.(1); KENNEDY A.D.(2)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina, USA; (2) Metabolon, Durham, North Carolina, USA
    The long-term health effects associated with cigarette smoking have been shown to be more harmful compared to those associated with the consumption of non-combustible tobacco products, such as moist snuff. In order to investigate the long-term health ...
  7. TSRC, Tob. Sci. Res. Conf., 2014, 68, abstr. 33

    Assessment of exposure biomarkers in U.S. consumers of snus, moist snuff, cigarettes, and dual use

    CARAWAY J.W.; JONES B.A.; CHEN P.; BORGERDING M.F.
    R.J. Reynolds Tobacco Company, Winston-Salem, North Carolina, USA
    Biomarkers of exposure (BoE) to constituents in tobacco products and tobacco smoke were assessed in adult, U.S. tobacco consumers who participated in a multi-center, cross-sectional study. A total of 320 subjects (267 males/53 females) were enrolled in ...
  8. TSRC, Tob. Sci. Res. Conf., 2013, 67, abstr. 31

    Biomarkers of tobacco effect: leukocyte subtypes as potential markers of inflammation in chronic tobacco consumers.

    PRASAD G.L.(1); ARIMILLI S.(2); CHEN P.(1); JONES B.A.(1)
    (1) R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA; (2) Wake Forest University School of Medicine, Winston-Salem, NC, USA
    Existing epidemiological data indicate that harm from smokeless tobacco consumption is significantly reduced compared to smoking, with no-tobacco-use being the least risky. Chronic cigarette smoking has been associated with increased inflammation and ...
  9. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPT 22

    Development of biomarkers of effect from chronic tobacco usage. Part 1: Study design and biomarkers of exposure

    JONES B.A.; CHEN P.; SCHMIDT E.; PRASAD G.L.
    R.J. Reynolds Tobacco Co., R&D Department, Winston-Salem, NC, USA
    To assess the effects of chronic exposure to combustible and non-combustible tobacco product use, a single site, cross-sectional clinical study was conducted. Three cohorts of healthy males (40/cohort, 35-60 years) were enrolled: long-term smokers and ...