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5 results

  1. Beitr. Tabakforsch. Int./Contrib. Tob. Research, 2008, 23-1, p. 19-31., ISSN.0173-783X

    Formation of tobacco specific nitrosamines in mainstream cigarette smoke; Part 1, FTC smoking

    MOLDOVEANU S.C.; BORGERDING M.F.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    This report evaluates the formation of nitrosonornicotine (NNN) and of 4-(methyl-nitrosamino)- 1-(3-pyridyl)- 1-buta-none (NNK) from nicotine, and of NNN from nornicotine in the mainstream smoke of a burning cigarette. The cigarettes analyzed in the study ...
  2. CORESTA Congress, Shanghai, 2008, SSPT 02

    Development of a risk-based priority toxicant list for smokeless tobacco products

    WILSON C.L.; POTTS R.J.; KRAUTTER G.R.; BODNAR J.A.; BORGERDING M.F.; GARNER C.D.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    Quantitative risk analysis (QRA) is an analytical process for quantifying the probability and potential impact of a defined risk. We have developed a priority toxicant list for comparing smokeless tobacco products by applying QRA principles based on ...
  3. CORESTA Congress, Shanghai, 2008, SSPT 08

    Cancer risk calculations for mainstream smoke constituents from selected cigarette brands: concordance between calculated and observed risk

    WILSON C.L.; POTTS R.J.; BODNAR J.A.; GARNER C.D.; BORGERDING M.F.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    A quantitative cancer risk assessment of mainstream smoke (MSS) constituents was performed for thirty-five (35) U.S. commercial cigarette brands. Products represented a broad range of "tar" yields (0.9 to 19 mg) as determined by machine smoking ...
  4. TSRC, Tob. Sci. Res. Conf., 2008, 62, abstr. 55

    Optimal quantitative analysis for urinary biomarkers of exposure of polycyclic aromatic hydrocarbons that vary in ring number: 1-hydroxy pyrene, 3-hydroxyphenanthrene, and 2-hydroxy benz[c]phenanthrene

    TAYLOR L.T.; ASHRAF- KHORASSANI M.; BORGERDING M.F.
    Virginia Tech, Blacksburg, VA, USA.
    Tobacco smoke, certain foods, and diesel exhaust are known to contain polycyclic aromatic hydrocarbons (PAHs). Historically, 1-hydroxypyrene (1-OHP), a metabolite of pyrene, has been the most commonly used biomarker of exposure to PAHs. More extensive ...