Search Results

116 results

  1. CORESTA Meeting, Agronomy/Phytopathology, 2019, Victoria Falls, AP 23

    Evaluation of contact and local-systemic sucker control products on flue-cured tobacco in Canada

    RICHMOND M.D.; SHEARER A.D.; ELLENBERGER E.; SAUDE C.; MISHRA S.; AMANKWA G.A.
    Canadian Tobacco Research Foundation, Tillsonburg, Ontario, Canada
    In Canada, control of axillary buds (suckers) for flue-cured tobacco is currently achieved through the use of long chain fatty alcohols, more specifically n-decanol (C10). Fatty alcohols are contact-type suckercides that must be applied in a way that ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 12

    Review of current methodologies in evaluating abuse liability of nicotine and tobacco products in the U.S. regulatory environment

    EVANS S.(1); KONG M.C.(2); CAMPBELL L.(2); SHERWOOD N.(3); PRASAD K.(4)
    (1) Turning Point Brands, Louisville, KY, U.S.A.; (2) Altasciences Clinical Research, Laval, Canada; (3) Neil Sherwood Consulting, Nyon, Switzerland; (4) British American Tobacco, R&D, Millbrook, Southampton, U.K.
    Traditional definitions of abuse and misuse do not apply to a consumer product such as tobacco that consumers essentially use ‘as intended’. In contrast to pharmaceutical products, a guidance for abuse liability testing of nicotine and tobacco products ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 30

    Assessment of within-package and lot-to-lot variability associated with quartz collection pads in the determination of metals in aerosol

    WAGSTAFF W.; JOZA P.; PAICO-AVILEZ H.; ZHENG T.; DONISA C.; RODRIGUEZ-LAFUENTE A.
    Labstat International Inc., Kitchener, ON, Canada
    Determining aerosol metals routinely requires an assessment of differences between test sample aerosol results and collection blanks. When using pad collection principles, the background levels associated with metals from the quartz pad can make the ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 44

    Lung biomarkers of harm/effect for tobacco regulatory research: opportunities and challenges – a literature review

    MAKENA P.(1); EDMISTON J.(2); BEATTIE E.(3); MASON E.(4); McEWAN M.(5); PRASAD K.(5)
    (1) RAI Services Company, Winston-Salem, NC, U.S.A.; (2) Altria Client Services LLC, Richmond, VA, U.S.A.; (3) Cliantha Research Limited, Canada; (4) Imperial Brands PLC, Bristol, U.K.; (5) British American Tobacco (Investments) Limited, Southampton, U.K.
    Biomarkers of potential harm (BoPH) are indicators of biological perturbations in response to smoking, which may contribute to smoking-related disease. In this review, a project of the CORESTA Biomarkers Sub-Group, we critically assessed the available ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 52 (also presented at TSRC 2019)

    Application of differential ion mobility spectrometry-tandem mass spectrometry for improved assay selectivity and sensitivity in the quantitation of tobacco biomarkers NNN, NNAL and 2-/3-HPMA in human urine

    PLOMLEY J.B.
    Altasciences, Laval, QC, Canada
    Differential ion mobility spectrometry (DMS) has recently emerged as an orthogonal gas-phase ion separation technique which, when interfaced between liquid chromatography (LC) and tandem mass spectrometry (MS/MS), promises improvements in both assay ...
  6. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 14

    Determination of untargeted compounds in e-liquids using high-performance liquid chromatography-time of flight-mass spectrometry (LC-ToF-MS)

    CHALCRAFT K.; JOZA P.; BIERNACKA P.; LI D.
    Labstat International Inc., Kitchener, ON, Canada
    Techniques like headspace-solid phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GCMS) can identify a wide range of volatile and semi-volatile compounds in e-liquids associated with flavor active compounds of different classes. The ...
  7. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 029

    Comprehensive insights into tobacco smoke using flow-modulated GCxGC-TOF MS

    LEMONS M.(1); McGREGOR L.(2); GREEN B.(2); BUCHANAN A.(2); EDWARDS M.(3)
    (1) Markes International, Sacramento, CA, USA; (2) SepSolve Analytical, Peterborough, UK; (3) SepSolve Analytical, Ontario, Canada
    From an analytical perspective, there is much that remains to be learnt about the composition of cigarette smoke, because of its high degree of complexity – tobacco smoke is thought to contain thousands of components across multiple chemical classes and ...
  8. TSRC, Tob. Sci. Res. Conf., 2019, 73, abstr. 044

    Abuse liability of very low nicotine content cigarettes with characterization of nicotine exposure profiles in adult smokers

    LEVY-COOPERMAN N.(1); SHRAM M.J.(1); KELSH D.(2); VINCE B.(2); CARMINES E.(3)
    (1) Altreos Research Partners, Toronto, ON, Canada; (2) Altasciences/Vince and Associates, Overland Park, KS, USA; (3) Carmines Consulting, Scottsdale, AZ, USA
    Objectives: In 2017, FDA announced the intention to explore limiting nicotine in cigarettes to minimal/non-addictive levels. Research indicates that reduced nicotine content would potentially limit reinforcing effects of cigarettes. We conducted 2 studies ...