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203 results

  1. CORESTA Meeting, Agronomy/Phytopathology, 2021, Online, AP 49

    Consequences of molecular genetic alteration of leaf nitrate levels on TSNAs, alkaloids, flowering time, and biomass in Burley tobaccos

    DEWEY R.E.(1); BOVET L.(2); GOEPFERT S.(2); CAMPANONI P.(2); LEWIS R.S.(1)
    (1) North Carolina State University, Dept. of Crop and Soil Sciences, Raleigh, NC, U.S.A.; (2) PMI R&D, Philip Morris Products S.A., Neuchatel, Switzerland
    We have previously demonstrated that tobacco-specific nitrosamine (TSNA) levels in Burley tobaccos can be substantially lowered using two distinct molecular genetic techniques designed to impede the plant’s ability to store high levels of free...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 01

    Development of consumer-reported outcome measure (CROM) standards for the tobacco industry with respect to psychometric CROM using a consortium-based approach: methodology and scope

    McCAFFREY S.(1) on behalf of the CORESTA CROM Task Force (WG02): AFOLALU E.(2); BLACK R.(1); CHREA C.(2); CURTIN G.(3); GILES L.(4); NISHIHARA D.(4); PRASAD K.(5); SARKAR M.(6); SHETTY M.(5)
    (1) JUUL Labs, Inc., San Francisco, CA, U.S.A.; (2) Philip Morris Products S.A., Neuchâtel, Switzerland; (3) RAI Services Company, Winston-Salem, NC, U.S.A.; (4) JT International S.A., Geneva, Switzerland; (5) British American Tobacco, Southampton, U.K.; (6) Altria Client Services, Richmond, VA, U.S.A.
    In November 2018, CORESTA approved the formation of a new Task Force (TF) to establish best practices and guidelines for the integration of consumer-reported outcome measures (CROM) in tobacco regulatory research. The primary objective of the CROM TF...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 02

    Descriptive consumer reported outcome measures and definitions in tobacco and nicotine research: a consensus approach

    WEI L.(1) on behalf of the CROM Task Force: CLERC E.(2); SHETTY M.(3); CHREA C.(2); PRASAD K.(3); SARKAR M.(1)
    (1) Altria Client Services LLC, Richmond, Virginia, U.S.A.; (2) Philip Morris International, Neuchâtel, Switzerland; (3) British American Tobacco, Southampton, U.K.
    The Consumer Reported Outcome Measures (CROM) Consortium Task Force (TF), consisting of academic researchers and members from various tobacco companies, was formed within the Cooperation Centre for Scientific Research Relative to Tobacco (CORESTA) in...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2021, Online, ST 45

    Meta-analysis study to establish population level estimates of NNAL in smokers and non-smokers

    AYALA-FIERRO F.(1); VERRON T.(2); LIZHNYAK P.(3); FREELAND R.(4); FROST-PINEDA K.(4); ELAMIN A.(5); PRASAD G.L.(4); SARKAR M.(3)
    (1) Juul Labs, Inc, U.S.A.; (2) Imperial Brands, U.K.; (3) Altria Client Services, U.S.A.; (4) RAI Services Company, U.S.A.; (5) Philips Morris International, Switzerland
    The purpose of this research (a project of the CORESTA Biomarkers Sub-Group) was to establish a population level estimate for the biomarker of cigarette smoke exposure, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), to serve as a baseline...
  5. TSRC, Tob. Sci. Res. Conf., 2021, 74, abstr. 32

    Development of recommendations of descriptive consumer-reported outcome measures (descriptive-CROM) and related definitions in tobacco and nicotine research

    WEI L.(1) on behalf of CORESTA CROM Task Force: CLERC E.(2); SHETTY M.(3); CHREA C.(2); PRASAD K.(3); SARKAR M.(1)
    (1) Altria Client Services LLC, Richmond, VA, USA; (2) Philip Morris International, Neuchâtel, Switzerland; (3) British American Tobacco, Southampton, UK
    Background: The Consumer Reported Outcome Measures (CROM) Consortium Task Force (TF), consisting of academic researchers and members from various tobacco companies, was formed within the Cooperation Centre for Scientific Research Relative to Tobacco...
  6. CROM Symposium, Online, 2020, CROM 01

    A consortium approach for consumer-reported outcome measures for assessing tobacco and nicotine-containing products

    ACQUADRO C.(1); AFOLALU E.F.(2); BLACK R.A.(3); CAHOURS X.(4); CHREA C.(2); CLERC E.(2); CURTIN G.(5); EVANS S.(6); GILES L.(7); MacCAFFREY S.(3); PARK H.(8); PRASAD K.(9); SARKAR M.(10); SHIFFMAN S.(11); WEI Lay(10)
    (1) ICON PLC, Lyon, France; (2) Philip Morris Products SA, Switzerland; (3) JUUL Labs, Inc., USA; (4) Imperial Brands, France; (5) RAI Services Company, USA; (6) Turning Point Brands, USA; (7) JT International SA, Switzerland; (8) KT&G Research Institute, Republic of Korea; (9) British American Tobacco, U.K.; (10) Altria Client Services, USA; (11) Pinney Associates, USA
    The continuum of risk of tobacco products is generally accepted among public health authorities, where combustible products like cigarettes are the most risky and noncombustible products are at the lower end of the continuum. Adult smokers (AS)...
  7. CROM Symposium, Online, 2020, CROM 05

    Establishing traceability of self-reported dependence measurement through the use of crosswalks

    SALZBERGER T.(1); CANO S.(2); ABETZ-WEBB L.(3); AFOLALU E.F.(4); CHREA C.(4); WEITKUNAT R.(4); ROSE J.(6)
    (1) WU Wien (University of Economics and Business), Institute for Statistics and Mathematics, Austria; (2) Modus Outcomes, UK; (3) Patient-Centered Outcomes Assessments, UK; (4) PMI R&D, Philip Morris Products S.A., Switzerland; (6) Rose Research Center, LLC, USA
    Measurement in the social sciences has been characterized by deficient justification and underdeveloped conceptual theories. Instruments supposed to measure the same measurand typically do not provide comparable measurements. From the perspective of...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 09

    The ABOUT™ Toolbox: toward the development of consumer-reported outcome measures that matter

    CHREA C.(1); SPIES E.(1); AFOLALU E.(1); BACSO A.(1); CLERC E.(1); MAINY N.(1); BINGGELI P.(1); WEITKUNAT R.(1); ACQUADRO C.(2); SALZBERGER T.(3); CANO S.(4); ABETZ-WEBB L.(5); ROSE J.(6)
    (1) PMI R&D, Philip Morris Products S.A., Neuchatel, Switzerland; (2) Mapi, an ICON plc Company, Lyon, France; (3) University of Economics and Business, Vienna, Austria; (4) ScaleReport, Ltd, Stotfold, U.K.; (5) Patient-Centered Outcomes Assessments, Ltd, Macclesfield Cheshire, U.K.; (6) Rose Research Center, Raleigh, U.S.A.
    Tobacco harm reduction promotes the substitution of reduced-risk products (RRPs) for cigarettes by adult smokers who would otherwise continue to smoke, while preventing RRP initiation among non-users. To operationalize this public health strategy,...
  9. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 11

    Development and validation of the ABOUT™–Dependence measurement instrument to assess perceived dependence on tobacco and nicotine products

    AFOLALU E.(1); CHREA C.(1); SALZBERGER T.(2); ABETZ-WEBB L.(3); CANO S.(4); WEITKUNAT R.(1); ROSE J.(5)
    (1) PMI R&D, Philip Morris Products S.A., Neuchatel, Switzerland; (2) University of Economics and Business, Vienna, Austria; (3) Patient-Centered Outcomes Assessments, Ltd, Macclesfield Cheshire, U.K.; (4) Modus Outcomes, Letchworth Garden City, U.K.; (5) Rose Research Center, Raleigh, U.S.A.
    The development of the ABOUT™–Dependence measurement instrument was initiated to enable assessment of perceived dependence associated with the use of different tobacco and nicotine products (TNPs) and in users of multiple TNPs. We initially developed...
  10. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 13

    Importance of e-liquid preparation and stability characterization for a combinatorial safety assessment approach of flavors in e-liquids

    GLABASNIA A.(1); DIANA P.(1); SMITH C.(2); MILLER J.H.(2); BIASIOLI M.(1); FRAUENDORFER F.(1); SCIUSCIO D.(1); MARTIN E.(1); POSPISIL P.(1); GUY P.(1); VANSCHEEUWIJCK P.(1); HOENG J.(1); KUMAR A.(2); LEE K.M.(2)
    (1) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (2) Altria Client Services LLC, Richmond, VA, U.S.A.
    Numerous flavorings are generally recognized as safe for use in food, but there is limited information available to evaluate their potential toxicity by inhalation. Consequently, gaining information on individual flavor safety levels is of...