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121 results

  1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 27

    Next generation product aerosol bubbled extracts show little to no effect in high content screening endpoints when compared to cigarette smoke bubbled extracts

    TRELLES STICKEN E.(1); WIECZOREK R.(1); BODE L.M.(1); SIMMS L.(2); STEVENSON M.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), BioToxLab, Hamburg, Germany; (2) Imperial Tobacco Limited, In vitro Research, Bristol, U.K.
    Tobacco-based and tobacco-free next generation products (NGPs) are understood to be a less harmful alternative to conventional combustible cigarettes. The objective of this study was to compare the in vitro biological response of cigarette smoke and a ...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 34

    Next generation product aerosols induce lower biological activity than combusted cigarettes: a comparison of in vitro cell migration in the scratch wound assay

    RUDD K.(1); BUDDE J.(2); TRELLES STICKEN E.(2); WIECZOREK R.(2); SIMMS L.(1); STEVENSON M.(1)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    Smoking combustible cigarettes is a cause of serious diseases in smokers, including heart disease. There are many commercially available next generation products (NGPs), such as tobacco-free e-vapour products, aiming to provide an alternative to smoking ...
  3. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STPOST 37

    Use of cell media nicotine concentration as a marker to predict cells surface deposited nicotine in transwells after fresh smoke/aerosol exposure

    WIECZOREK R.(1); TRELLES STICKEN E.(1); BODE L.M.(1); SIMMS l.(2)
    (1) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (2) Imperial Tobacco Limited, Bristol, U.K.
    Exposure of organotypic 3D lung models at the air liquid interface (ALI) to fresh whole smoke/aerosol provides a more human relevant exposure assessment of combustible cigarettes and e-vapour products. The aim of this study is to present a method for ...
  4. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 01

    The application of in vitro Toxicity Testing in 21 Century (TT21C) for next generation products

    SIMMS L.(1); TRELLES STICKEN E.(2)
    (1) Imperial Brands PLC, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    The aim is to demonstrate the feasibility of TT21C in vitro methods as part of an overall assessment framework for next generation products (NGP). TT21C methodologies can be used to assess harm reduction potential of NGPs using human-derived cellular ...
  5. CORESTA Meeting, Agronomy/Phytopathology, 2017, Santa Cruz do Sul, AP 53

    Interactions between tobacco bushy top virus and its satellite RNA

    MO Xiaohan(1); ZHANG Lifang(1,2); ZHAO Xingneng(1,2); XU Ping(1,2); LI Yanqiong(1,2); XIA Zhenyuan(1); QIN Xiyun(1); CHEN Hairu(2)
    (1) Yunnan Academy of Tobacco Agricultural Sciences, Kunming, P.R. China; (2) College of Plant Protection, Yunnan Agricultural University, Kunming, P.R. China
    Tobacco bushy top disease (TBTD) has caused significant yield and economic losses in Yunnan Province, China. The disease is caused by an unique virus complex consisting of tobacco bushy top virus (TBTV), TBTV satellite RNA, tobacco vein distorting virus, ...
  6. TSRC, Tob. Sci. Res. Conf., 2017, 71, abstr. 123

    The regulation of microorganism on the formation of TSNAs in tobacco

    ZOU Congming; XIA Zhenyuan; LEI Liping; HUANG Wei; ZHAO Gaokun; JIN Yan; WU Qun
    Yunnan Academy of Tobacco Agricultural Sciences, Kunming, China
    TSNAs in tobacco are directly approved to be the carcinogens which is getting more and more attention than before. The regulation of TSNAs is becoming one of the most important topics of tobacco harm reduction. It has been shown that TSNAs formation is ...
  7. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, APPOST 26

    Crop compliance: crop protection agents testing programme within purchases

    BODE L.M.; EVANS W.; INTORP M.
    Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    In order to ensure the compliance of our products, leaf grade purchases are monitored for the presence of any residual crop protection agents (CPA). CPA residue levels are first assessed for compliance against limits set by regulatory authorities and ...
  8. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 35

    Development of a method for trace level analysis in the aerosol from a novel tobacco vaporiser

    MASUGI E.(1); SASAMOTO K.(2); OCHIAI N.(2); DAVID F.(3); SANDRA P.(3)
    (1) Japan Tobacco Inc. Tobacco Science Research Center, Yokohama, Kanagawa, Japan; (2) GERSTEL K.K., Tokyo, Japan; (3) Research Institute for Chromatography, Kortrijk, Belgium
    In some markets, a variety of tobacco vaporisers is commercially available. One of the characteristics of tobacco vaporisers is that the generated aerosol contains a lower number of combustion-derived chemicals due to the particular heating system which ...
  9. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 04

    Impact of different vaping machines on metal contaminations of e-cigarette aerosols

    OTTE S.; NOWAK S.; INTORP M.
    Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany
    The presence of trace metals in e-liquids or aerosol of electronic cigarettes (e-cigarette) has been previously reported [1]. It has also been demonstrated that contamination with tin, aluminum, copper, iron and nickel may occur from certain parts of a ...
  10. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 26

    A review of aerosol exposure systems relative to the analysis of cytotoxicity: a CORESTA In vitro Toxicity Testing Sub-Group perspective

    THORNE D.(1); WIECZOREK R.(2); FUKUSHIMA T.(3); SHIN H.J.(4); LEVERETTE R.(5); BALLANTYNE M.(6); LI X.(7); BOMBICK B.(5)
    (1) British American Tobacco, R&D Centre, Southampton, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (3) Japan Tobacco Inc., Scientific Product Assessment Centre, Yokohama, Kanagawa, Japan; (4) KT&G Corporation, Daejeon, South Korea; (5) RAI Services Company, Winston-Salem, NC, U.S.A.; (6) Covance Laboratories Ltd, Harrogate, U.K.; (7) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou, P.R. China
    Aerosol exposure systems offer researchers a variety of ways to customise the exposure set-up, modify experimental parameters and provide a novel and versatile platform for in vitro aerosol research. These systems produce an aerosol that more closely ...