Search Results

18 results

  1. TSRC, Tob. Sci. Res. Conf., 2018, 72, abstr. 049

    Assessment of in vitro toxicity/genotoxicity of ends and combustible products

    JORDAN K.(1); BOMBICK B.(1); COOPER B.(1); LEVERETTE R.(1); SHUTSKY T.(1); WEST C.(1); STRASSER J.(1); ROUND E.(1); MARANO K.M.(1); MOMIN R.(2); TRIVEDI A.(2); WAGSTAFF W.(2); BRUCE S.(3); DAKOULAS E.(3); ROY S.(3)
    (1) RAI Services Company, Winston-Salem, NC, USA; (2) Labstat International ULC, Kitchener, ON, Canada; (3) BioReliance Corp, Rockville, MD, USA
    In May 2016, the U.S. Food and Drug Administration Center for Tobacco Products (CTP) issued draft guidance for Premarket Tobacco Product Applications (PMTA) for Electronic Nicotine Delivery Systems (ENDS), which recommends inclusion of in vitro toxicology ...
  2. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, ST 35

    Development of a method for trace level analysis in the aerosol from a novel tobacco vaporiser

    MASUGI E.(1); SASAMOTO K.(2); OCHIAI N.(2); DAVID F.(3); SANDRA P.(3)
    (1) Japan Tobacco Inc. Tobacco Science Research Center, Yokohama, Kanagawa, Japan; (2) GERSTEL K.K., Tokyo, Japan; (3) Research Institute for Chromatography, Kortrijk, Belgium
    In some markets, a variety of tobacco vaporisers is commercially available. One of the characteristics of tobacco vaporisers is that the generated aerosol contains a lower number of combustion-derived chemicals due to the particular heating system which ...
  3. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 32

    Cellular transformation activity of different tobacco condensates in the Bhas 42 cell assay

    STEVENSON M.(1); WIECZOREK R.(2); SIMMS L.(1); PANT K.(3)
    (1) Imperial Tobacco Limited, Bristol, U.K.; (2) Reemtsma Cigarettenfabriken GmbH (an Imperial Brands PLC Company), Hamburg, Germany; (3) BioReliance, Sigma-Aldrich Corp., Rockville, MD, U.S.A.
    Carcinogenesis has been described as a multi-stage process comprising of initiation, promotion and progression. Smoking is a cause of serious disease in smokers, including lung cancer. Determining the carcinogenic potential of a tobacco product ingredient ...
  4. CORESTA Congress, Berlin, 2016, Smoke Science/Product Technology Groups, STPOST 35

    Comparison of the carcinogenic potential of tobacco smoke and electronic-cigarette aerosol using the Bhas cell transformation assay

    BREHENY D.(1); OKE O.(1); PANT K.(2); BRUCE S.W.(2); LAFORCE M.K.(2); CELESTIN N.(2); GAÇA M.D.(1)
    (1) British American Tobacco, R&D Centre, Southampton, U.K.; (2) BioReliance, Sigma-Aldrich Corp., Rockville, MD, U.S.A.
    In vitro cell transformation assays (CTA) are used to assess the carcinogenic potential of chemicals and complex mixtures. They can detect non-genotoxic as well as genotoxic carcinogens. The Bhas 42 CTA has been developed with both initiation and ...
  5. CORESTA Meeting, Smoke Science/Product Technology, 2015, Jeju, ST 36

    Comprehensive analysis of proteins in tobacco leaf

    MASUGI E.(1); ORTIZ A.(2); YOSHIMURA Y.(1); MITSUI K.(1); DAVID F.(2); SANDRA P.(2); SANDRA K.(2)
    (1) Japan Tobacco Inc., Tobacco Science Research Center, Yokohama, Kanagawa, Japan; (2) Research Institute for Chromatography, Kortrijk, Belgium
    In the last two decades, proteomics has been a vastly expanding field of research. Proteomics aims at the comprehensive and comparative measurement of the proteins present in a sample, e.g. plants. Major developments in separation and analytical sciences ...
  6. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 14

    Water pipe tobacco smoking – from the first idea to an international standard

    HAHN J.(1); ROSE N.(2)
    (1) Chemisches und Veterinäruntersuchungsamt Sigmaringen, Sigmaringen, Germany; (2) Borgwaldt KC GmbH, Hamburg, Germany
    The presentation is divided into two parts: The first part concerns the requirement for a standardised method in general. It points out the reasons why the German national standardisation body DIN initialised the project within the ISO/TC 126. It also ...
  7. CORESTA Congress, Quebec, 2014, Smoke Science/Product Technology Groups, ST 45

    Comprehensive analysis of lipid compounds in tobacco leaf

    MASUGI E.(1); DUNKLE M.(2); t'KINT R.(2); MITSUI M.(1); OCHIAI N.(3); DAVID F.(2); SANDRA K.(2); SANDRA P.(2)
    (1) Japan Tobacco Inc. Tobacco Science Research Center, Yokohama, Kanagawa, Japan; (2) Research Institute for Chromatography, Kortrijk, Belgium; (3) GERSTEL K.K., Tokyo, Japan
    In recent years, lipidomics has been a vastly expanding field of research due to the development of new technologies in liquid chromatography and from recognising the role of lipids in metabolism. Tobacco leaf consists of thousands of chemical compounds ...
  8. CORESTA Meeting, Smoke Science/Product Technology, 2013, Seville, ST 30

    Application of multidimensional GC in combination with tandem mass spectrometry and accurate mass detection for identification of sulphur compounds in tobacco smoke extract

    MITSUI K.(1); YOSHIMURA Y.(1); OCHIAI N.(2); SASAMOTO K.(2); NAGATA H.(1); DAVID F.(3); SANDRA P.(3)
    (1) Japan Tobacco Inc., Tobacco Science Research Center, Yokohama, Japan; (2) Gerstel K.K., Tokyo, Japan; (3) Research Institute for Chromatography, Kortrijk, Belgium
    Tobacco smoke is a highly complex mixture of a wide variety of chemical compounds including sulphur-containing compounds which are present at very low concentrations and have low odour thresholds. From past studies, it is well known that required ...
  9. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, PT 08

    Heart-cutting two-dimensional GC in combination with isotope ratio mass spectrometry for the characterisation of lipids in tobacco leaves and smoke

    DAVID F.(1); DUMONT E.(1); TIENPONT B.(1); MITSUI K.(2); OCHIAI N.(3); KANDA H.(3); HIGASHI N.(2); SANDRA P.(1)
    (1) Research Institute for Chromatography, Kortrijk, Belgium; (2) Japan Tobacco Inc., Tobacco Science Research Center, Yokohama, Japan; (3) Gerstel K.K., Tokyo, Japan
    During the last few years, interest in isotope ratio mass spectrometry (IRMS) has increased tremendously. IRMS is used for the determination of the origin/source of products and for adulteration detection. Application areas include natural product ...
  10. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SS 14

    Applying gas chromatography with soft ionisation mass spectroscopy for the characterisation of tobacco leaves and tobacco smoke

    DAVID F.(1); TIENPONT B.(1); MITSUI K.(2); OCHIAI N.(3); SASAMOTO K.(3); HIGASHI N.(2); SANDRA P.(1)
    (1) Research Institute for Chromatography, Kortrijk, Belgium; (2) Japan Tobacco Inc., Tobacco Science Research Center, Yokohama, Japan; (3) Gerstel K.K., Tokyo, Japan
    In this presentation, the applicability of GC in combination with atmospheric pressure chemical ionisation mass spectroscopy (APCI-MS) and with supersonic molecular beam ionisation mass spectroscopy (SMB-MS) will be demonstrated for the characterisation ...