TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 21
Estimation of nicotine uptake from tobacco products in dual-use vs. abstinence study designs
R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
RJRT has explored two approaches for determining nicotine uptake from use of smokeless tobacco products (STPs) and cigarettes in smokers. In a “dual use” design, subjects smoked ad libitum until 30 minutes before in-clinic assessment. Subject assessment ...