Search Results

6 results

  1. CORESTA Congress, Edinburgh, 2010, SS 02; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 34

    A clinical trial of cardiovascular disease biomarkers in adult smokers and moist snuff consumers. Part I: study design, subject selection and cohort characterization

    JONES B.A.; BROWN B.G.; LEE L.C.; HEAVNER D.L.; STEICHEN T.J.; BORGERDING M.F.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    A single site, three cohort, age-stratified, cross-sectional study was conducted in the US in subjects who were exclusive cigarette smokers (n=60), exclusive moist snuff consumers (n=48), and non-consumers of tobacco (n=60) to identify potential...
  2. CORESTA Congress, Edinburgh, 2010, SS 03; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 35

    Cardiovascular disease biomarkers study, Part II: Tobacco-related biomarkers of exposure in exclusive cigarette smokers, exclusive moist snuff consumers, and non-consumers of tobacco.

    BROWN B.G.; JONES B.A.; LEE L.C.; HEAVNER D.L.; STEICHEN T.J.; BORGERDING M.F.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    A CVD biomarkers study conducted in the US measured putative tobacco-related biomarkers in three exclusive cohorts: cigarette smokers, moist snuff consumers and non-consumers of tobacco. Subjects were generally healthy males between the ages of...
  3. CORESTA Congress, Edinburgh, 2010, SS 04; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 36

    Cardiovascular disease biomarkers study, Part III: Tobacco-related biomarkers of effect in exclusive cigarette smokers, exclusive moist snuff consumers, and non-consumers of tobacco

    NORDSKOG B.K.; BROWN B.G.; JONES B.A.; HEAVNER D.L.; STEICHEN T.J.; BORGERDING M.F.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    A three cohort, age-stratified cross-sectional study was conducted in the U.S. in cigarette smokers (n=60), moist snuff consumers (n=48) and non-consumers of tobacco (n=60) to evaluate several known cardiovascular biomarkers of effect. Subject...
  4. CORESTA Congress, Edinburgh, 2010, SSPTPOST 13; TSRC, Tob. Sci. Res. Conf., 2010, 64, abstr. 08

    Clinical methodology and results for physiological assessments including flow-mediated dilation, carotid intima-media thickness, ankle brachial index, spirometry, and expired carbon monoxide in exclusive cigarette smokers, exclusive moist snuff consumers and non-consumers of tobacco

    BROWN B.G.; JONES B.A.; NORDSKOG B.K.; HEAVNER D.L.; STEICHEN T.J.; BORGERDING M.F.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    Several physiological assessments have been reported in the literature as measures for detecting, predicting and monitoring cardiovascular disease (CVD). These non-invasive techniques were investigated in three exclusive all male cohorts (cigarette...
  5. CORESTA Congress, Kyoto, 2004, SS 01

    Individual variations in cigarette mainstream smoke biomarkers of exposure

    DOOLITTLE D.J.; SMITH C.J.; MORTON M.J.; BOMBICK D.W.; BROWN B.G.; HEAVNER D.L.; MORGAN W.T.; OGDEN M.W.; ROBINSON J.H.
    R.J. Reynolds Tobacco Company, Winston-Salem, NC, USA
    Biomarkers of tobacco smoke exposure were measured in urine and buccal cells from 56 smokers of full-flavor low 'tar' (FFLT) cigarettes to evaluate the degree of individual variation. Biomarkers were measured while each individual smoked their usual...
  6. Bull. Spec. CORESTA Congress, Brighton, 1998, p. 169, ST21

    The inhibitory effect of cotinine or cigarette smoke on the formation of O<sup>6</sup>-methylguanine adducts in the lung and liver of A/J mice treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)

    DOOLITTLE D.J.; BROWN B.G.; AYRES P.H.; CHANG C.J.G.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine, induces lung adenomas in A/J mice following a single intraperitoneal (i.p.) injection. NNK-induced lung tumorigenesis is thought to involve O6-methylguanine (O6MeG)...