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6 results

  1. Beitr. Tabakforsch. Int./Contrib. Tob. Research, 2007, 22-4, p. 290-302., ISSN.0173-783X

    Differences in the chemical composition of the particulate phase of inhaled and exhaled cigarette mainstream smoke

    MOLDOVEANU S.C.; ST. CHARLES F.K.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    In this study, a comparison between the chemical composition of the particulate-phase of exhaled smoke and that of smoke generated with a smoking machine has been performed. For this purpose, eight human subjects smoked a common Lights (10.6 mg 'tar ...
  2. CORESTA Meeting, Smoke Science/Product Technology, Jeju, 2007, IG 02, Agronomy/Phytopathology, Krakow, 2007, IG 02

    An effective product evaluation strategy for PREP cigarettes

    DOOLITTLE D.J.; COOK C.J.; WILSON C.L.
    R.J. Reynolds Tobacco Company, R&D, Winston-Salem, NC, USA
    Cigarette smoking has been shown to substantially increase the risk of a number of diseases; including lung cancer, pulmonary disease and heart disease. There is agreement among many stakeholders that the development of potentially reduced exposure ...
  3. CORESTA Meeting, Smoke Science/Product Technology, Jeju, 2007, SSPTPOST 15

    A ring trial test of nicotine uptake determinations by multiple laboratories

    BYRD G.; OGDEN M.
    R.J. Reynolds Tobacco Company, Human Studies Division, Winston-Salem, NC, USA
    Total nicotine uptake by smokers is best determined by measuring nicotine and its major metabolites (usually five) in 24-h urine samples. Of additional interest is the primary metabolite cotinine in saliva since it is also related to total nicotine uptake ...
  4. TSRC, Tob. Sci. Res. Conf., 2007, 61, abstr. 23

    Genes involved in inflammatory responses following exposure to cigarette smoke in normal human bronchial epithelial (NHBE) cells

    PARSANETAD R.; FIELDS W.R.; STEICHEN T.J.
    Wake Forest University School of Medicine, Dept. of Physiology and Pharmacology, Winston-Salem, NC, USA
    Bronchial epithelium is frequently exposed to air pollutants. Hence, it has been hypothesized that these cells elicit inflammatory responses as the first element in pulmonary defense. The purpose of this study is to evaluate changes in mRNA levels of 84 ...