1. CORESTA Congress, Sapporo, 2012, Plenary Session, abstr. IG 02

    Levels of tobacco-specific N-nitrosamines NNN and NNK in commercial cigarettes sampled in2008-2010 – A review of analytical data

    GUNDUZ I.(1); KONDYLIS A.(1); HOFER R.(1); JACCARD G.(2); RUFFIEUX L.(3); GADANI F.(1)
    (1) Philip Morris Products SA, Product Development – Applied Cigarette Research, Neuchatel, Switzerland; (2) Philip Morris International Management SA, Product and Process Quality, Neuchatel, Switzerland; (3) Philip Morris International Management SA, Agricultural Programs, Lausanne, Switzerland
    The present study was designed to determine levels of the tobacco-specific N-nitrosamines (TSNAs) N’-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in tobacco cut filler and in mainstream smoke of commercial...
  2. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, PT 05

    Impact of cigarette paper properties on smoke constituents’ delivery under Health Canada Intense smoking regime

    GUYARD A.; MEIER D.; CECCHETTO A.; HOFER R.; LI P.
    Philip Morris Products SA, Product Development – Applied Cigarette Research, Neuchatel, Switzerland
    This investigation was undertaken to assess to which extent the changes of cigarette paper characteristics may impact the delivery of nine cigarette smoke constituents when measured under Health Canada Intense (HCI) smoking regime and normalised to...
  3. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, PT 07

    Improved methods for the determination of crop protection agent residues in tobaccos and tobacco products by LC-MS/MS using the QuEChERS extraction

    DEGER A.; JACCARD G.
    Philip Morris International Management SA, Product and Process Quality, Neuchatel, Switzerland
    We will present two improved methods to determine Crop Protection Agent (CPA) residues in tobaccos and tobacco products and discuss their development and validation. The methods are applicable to 53 of the 118 CPA recommended in the CORESTA Guide...
  4. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SS 02

    Development of a systems toxicology approach and its application to quantify the biological impact of tobacco smoke in vitro and in vivo

    PEITSCH M.C.; MATHIS C.; WAGNER S.; KOGEL U.; POUSSIN C.; SCHLAGE W.; STINN W.; MEURRENS K.; WEISENSEE D.; GEBEL S.; BELCASTRO V.; XIANG Y.; MARTIN F.; SEWER A.; HENGSTERMANN A.; ANSARI A.; HOENG J.
    Philip Morris International R&D, Philip Morris Products SA, Neuchâtel, Switzerland
    The potential health risks of long-term exposure to biologically active substances such as therapeutic drugs or environmental toxins are frequently determined a posteriori through clinical epidemiology studies. However, disease may take decades to...
  5. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 28

    CSEO – The cigarette smoke exposure ontology

    YOUNESI E.(1), COGGINS C.(2); ANSARI S.(3); HOENG J.(3); PEITSCH M.(3); HOFMANN-APITIUS M.(1)
    (1) Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Sankt Augustin, Germany; (2) Carson Watts Consulting, King, NC, USA; (3) Philip Morris International R&D, Neuchâtel, Switzerland
    In the past years, significant progress has been made in the development and use of experimental settings for collection of massive and precise experimental data on tobacco exposure and the diseases induced by it. Despite the growing number of such...
  6. Tobacco Science & Technology, 2012, 6, p. 72-75, ISSN.1002-0861

    Fungal biosorbent produced by fermentation of waste tobacco stems and its decolorization effect

    XI Yu(1); GAO Ming(2); GUO Dongheng(1); LI Junxia(1); LI Guanglei(1); WANG Xifeng(1); WANG Yanyan(1); ZHU Daheng(*1)
    (1) Department of Bioengineering, Zhengzhou University, Zhengzhou 450001, P.R. China; (2) Yellow River Basin Water Resources Protection Bureau, Zhengzhou 450004, P.R. China
    A high-efficient decolorizing fungus was screened from the product of solid state fermentation of waste tobacco stems and named as LY7. By its morphological and microscopic characteristics, LY7 was preliminarily identified as Penicillium sp. LY7...