1. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 30

    Effects of exposure to e-cigarette aerosols compared with cigarette smoke on 3D human buccal and small airway cultures: a systems toxicology assessment

    ISKANDER A.(1); STEINER S.(1); MAJEED S.(1); KONDYLIS A.(1); XIANG Yang(1); ZANETTI F.(1); FRENTZEL S.(1); MARTIN F.(1); PEITSCH M.C.(1); DOSHI U.(2); McKINNEY W.J.(2); LEE K.M.(2); HOENG J.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond VA, U.S.A.
    Considerable attention has been given toward the reduced risk potential of e-cigarettes (e-cigs). Most in vitro studies have focused on testing e-liquid formulations directly on submerged 2D cultures. Here, we examined the effects of exposure to the whole ...
  2. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 48

    Six-month systems toxicology inhalation/cessation study in ApoE-/- mice to investigate cardiovascular and respiratory exposure effects of two reduced risk tobacco products compared with conventional cigarettes

    PHILLIPS B.(2); SZOSTAK J.(1); HO J.(2); GUEDJ E.(1); WONG Ee Tsin(2); TALIKKA M.(1); LEBRUN S.(1); TITZ B.(1); MARTIN F.(1); VUILLAUME G.(1); LEROY P.(1); IVANOV N.(1); VANSCHEEUWIJCK P.(1); PEITSCH M.C.(1); HOENG J.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Philip Morris International Research Laboratories Pte. Ltd., (part of Philip Morris International group of companies), PMI R&D, Singapore
    Cigarette smoking causes adverse health effects that may occur shortly after smoking initiation and lead to the development of cardiovascular disease, respiratory disease (chronic obstructive pulmonary disease), and various cancers. To reduce the risk of ...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 61

    A 6-month inhalation study in Apoe-/- mice to investigate cardiovascular and respiratory exposure effects of e-vapor aerosols compared with cigarette smoke

    WONG Ee Tsin(1); SZOSTAK J.(2); KRISHNAN S.(1); TAN Wei Teck(1); SEOW E.(1); TENG C.(1); LEE K.M.(3); ZHANG Jingjie(3); McKINNEY W.J.(3); PEITSCH M.C.(2); VANSCHEEUWIJCK P.(2); HOENG J.(2)
    (1) Philip Morris International Research Laboratories Pte. Ltd., (part of Philip Morris International group of companies), PMI R&D, Singapore; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (3) Altria Client Services LLC, Richmond, VA, U.S.A.
    Chronic exposure to cigarette smoke is a risk factor for the development and progression of cardiovascular disease and chronic obstructive pulmonary disease. Considerable attention has been given towards the potential reduced harm of e cigarettes (e cigs) ...
  4. CORESTA Congress, Berlin, 2016, Agronomy/Phytopathology Groups, AP 22

    Nicotiana genomes: beyond tobacco

    SIERRO N.S.; BATTEY J.N.D.; OUADI S.; THOMAS J.; LIEDSCHULTE V.; BOVET L.; BROYE H.; LAPARRA H.; VUARNOZ A.; LANG G.; GOEPFERT S.; PEITSCH M.C.; IVANOV N.V.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    While Nicotiana tabacum is likely the most notable species from the Nicotiana genus, various other Nicotiana species are cultivated as crops, grown as ornamental garden plants, or used as model organisms in research. Within Solanaceae, Nicotiana species ...
  5. CORESTA Meeting, Agronomy/Phytopathology, 2015, Izmir, Turkey, APW 02

    The tobacco genome sequence

    SIERRO N.; BATTEY J.N.D.; OUADI S.; BAKAHER N.; BOVET L.; WILLIG A.; GOEPFERT S.; PEITSCH M.C.; IVANOV N.V.
    Philip Morris Products S.A., PMI R&D, Neuchâtel, Switzerland
    Nicotiana tabacum (common tobacco) is a major crop species and a model organism, for which only very fragmented genomic sequences have been available until recently. The three most commonly used tobacco types are flue-cured (or Virginia), Burley and ...
  6. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SS 02

    Development of a systems toxicology approach and its application to quantify the biological impact of tobacco smoke in vitro and in vivo

    PEITSCH M.C.; MATHIS C.; WAGNER S.; KOGEL U.; POUSSIN C.; SCHLAGE W.; STINN W.; MEURRENS K.; WEISENSEE D.; GEBEL S.; BELCASTRO V.; XIANG Y.; MARTIN F.; SEWER A.; HENGSTERMANN A.; ANSARI A.; HOENG J.
    Philip Morris International R&D, Philip Morris Products SA, Neuchâtel, Switzerland
    The potential health risks of long-term exposure to biologically active substances such as therapeutic drugs or environmental toxins are frequently determined a posteriori through clinical epidemiology studies. However, disease may take decades to ...