1. CORESTA Congress, Sapporo, 2012, Plenary Session, abstr. IG 02

    Levels of tobacco-specific N-nitrosamines NNN and NNK in commercial cigarettes sampled in2008-2010 – A review of analytical data

    GUNDUZ I.(1); KONDYLIS A.(1); HOFER R.(1); JACCARD G.(2); RUFFIEUX L.(3); GADANI F.(1)
    (1) Philip Morris Products SA, Product Development – Applied Cigarette Research, Neuchatel, Switzerland; (2) Philip Morris International Management SA, Product and Process Quality, Neuchatel, Switzerland; (3) Philip Morris International Management SA, Agricultural Programs, Lausanne, Switzerland
    The present study was designed to determine levels of the tobacco-specific N-nitrosamines (TSNAs) N’-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in tobacco cut filler and in mainstream smoke of commercial...
  2. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, PT 05

    Impact of cigarette paper properties on smoke constituents’ delivery under Health Canada Intense smoking regime

    GUYARD A.; MEIER D.; CECCHETTO A.; HOFER R.; LI P.
    Philip Morris Products SA, Product Development – Applied Cigarette Research, Neuchatel, Switzerland
    This investigation was undertaken to assess to which extent the changes of cigarette paper characteristics may impact the delivery of nine cigarette smoke constituents when measured under Health Canada Intense (HCI) smoking regime and normalised to...
  3. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, PT 07

    Improved methods for the determination of crop protection agent residues in tobaccos and tobacco products by LC-MS/MS using the QuEChERS extraction

    DEGER A.; JACCARD G.
    Philip Morris International Management SA, Product and Process Quality, Neuchatel, Switzerland
    We will present two improved methods to determine Crop Protection Agent (CPA) residues in tobaccos and tobacco products and discuss their development and validation. The methods are applicable to 53 of the 118 CPA recommended in the CORESTA Guide...
  4. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SS 02

    Development of a systems toxicology approach and its application to quantify the biological impact of tobacco smoke in vitro and in vivo

    PEITSCH M.C.; MATHIS C.; WAGNER S.; KOGEL U.; POUSSIN C.; SCHLAGE W.; STINN W.; MEURRENS K.; WEISENSEE D.; GEBEL S.; BELCASTRO V.; XIANG Y.; MARTIN F.; SEWER A.; HENGSTERMANN A.; ANSARI A.; HOENG J.
    Philip Morris International R&D, Philip Morris Products SA, Neuchâtel, Switzerland
    The potential health risks of long-term exposure to biologically active substances such as therapeutic drugs or environmental toxins are frequently determined a posteriori through clinical epidemiology studies. However, disease may take decades to...
  5. CORESTA Congress, Sapporo, 2012, Smoke Science/Product Technology Groups, SSPT 21 (Poster)

    Analysis of stimulation on oral cavity caused by three kinds of volatile compounds in mainstream cigarette smoke

    CAO Yi; ZHUANG Ya-dong; ZHU Huai-yuan; WAN Min; LIU Xian-jun; SHEN Xiao-chen; ZHANG Yuan; ZHANG Ying; XIONG Xiao-min
    Research and Development Center of China Tobacco Jiangsu Industrial Co., Ltd., Nanjing, Jiangsu, P.R. China
    Cigarette smoke stimulation is mainly evaluated by sensory evaluation. In order to analyse smoke stimulation on the oral cavity qualitatively and quantitatively, a set of oral simulators was designed by taking three kinds of stimulating compounds...
  6. TSRC, Tob. Sci. Res. Conf., 2012, 66, abstr. 28

    CSEO – The cigarette smoke exposure ontology

    YOUNESI E.(1), COGGINS C.(2); ANSARI S.(3); HOENG J.(3); PEITSCH M.(3); HOFMANN-APITIUS M.(1)
    (1) Fraunhofer Institute for Algorithms and Scientific Computing SCAI, Sankt Augustin, Germany; (2) Carson Watts Consulting, King, NC, USA; (3) Philip Morris International R&D, Neuchâtel, Switzerland
    In the past years, significant progress has been made in the development and use of experimental settings for collection of massive and precise experimental data on tobacco exposure and the diseases induced by it. Despite the growing number of such...
  7. Tobacco Science & Technology, 2012, 11, p. 20-22, 25, ISSN.1002-0861

    Improvement of moisture content control system in HAUNI ordering cylinder

    DONG Wei; LI Kun; WANG Jian; ZHAO Yu; YAN Junmin
    Xuzhou Cigarette Factory, China Tobacco Jiangsu Industrial Co., Ltd., Xuzhou 221005, Jiangsu, P.R. China
    In order to minimized the fluctuation of output moisture content in tobacco, the control system in HAUNI’s ordering cylinder was modified as follows: 1) a closed loop control system was designed for the output end of the cylinder, to feed the value...
  8. Tobacco Science & Technology, 2012, 11, p. 33-37, ISSN.1002-0861

    Application of fuzzy judgment and Euclidean distance method in evaluation of chemical components in flue-cured tobacco leaf

    HU Zhongsheng; CHEN Jingbo; ZHOU Xinghua; ZHAO Qibai*; XU Zhiqiang
    China Tobacco Jiangsu Industrial Co., Ltd., Nanjing 210019, P.R. China
    In order to scientifically assess the chemistry of tobacco leaf, 9 chemical indices (including nicotine, total sugar, reducing sugar, total nitrogen, potassium, chlorine, sugar/nicotine ratio, nitrogen/nicotine ratio and potassium/chlorine ratio) of...
  9. Tobacco Science & Technology, 2012, 4, p. 28-32, ISSN.1002-0861

    Determination of hydrogen peroxide in mainstream cigarette smoke by highly selective fluorescence method with Amplex Red/HRP

    PENG Shuhai(1); ZHANG Ying(2); LIU Hailin(1); ZHUANG Yadong(2); JIANG Chengyong(1); SUN Shihao(1); ZONG Yongli(1); XIE Jianping(1)
    (1) Zhengzhou Tobacco Research Institute of CNTC, Zhengzhou 450001, P.R. China; (2) Technology and Research Center, China Tobacco Jiangsu Industrial Co., Ltd., Nanjing 210093, P.R. China
    A highly selective fluorescence method with Amplex Red HRP was developed to determine the hydrogen peroxide in mainstream cigarette smoke. This method’s LOD=13.5 nmol/L, recovery 98.3 %-101.7 % and RSD<3.17 % (n=5). The level of hydrogen peroxide...
  10. Tobacco Science & Technology, 2012, 8, p. 29-33, 39, ISSN.1002-0861

    Uncertainty in determination of total alkaloids in flue-cured tobacco with continuous flow method

    ZHANG Wei(1); WANG Ying(1); TANG Gangling(*1); SHAN Hongguang(1); XU Ruyan(2); WANG Xiaochun(2); FAN Guomin(3)
    (1) China National Tobacco Quality Supervision & Test Center, Zhengzhou 450001, P.R. China; (2) Xuzhou Cigarette Factory, China Tobacco Jiangsu Industrial Co., Ltd., Xuzhou 221005, Jiangsu, P.R. China; (3) Zhumadian Cigarette Factory, China Tobacco Henan Industrial Co., Ltd., Zhumadian 463000, Henan, P.R. China
    In order to evaluate the uncertainty in the determination of total alkaloids in flue-cured tobacco with continuous flow method, the cause-effect relationship diagram in the determination was revised and a new mathematical model for measurement...