CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, ST 47
A high-throughput and sensitive bioanalytical method for quantification of nicotine and cotinine in rat/mouse plasma using reversed-phase liquid chromatography–tandem mass spectrometry and its application in inhalation study sample analysis
(1) PMI R&D, Philip Morris International Research Laboratories Pte. Ltd., Singapore; (2) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
Nicotine and cotinine are used as primary biomarkers to estimate the exposure of reduced-risk products, such as e-liquids/heated tobacco products, in comparison with cigarettes. The objective of this study was to develop and validate a method per...