Search Results

218 results

  1. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 10

    Testing performance of tobacco varieties in water stress conditions

    CAMPANONI P.(1); LAPARRA H.(1); OZELLEY P.(1); DELLA CIANA P.(3); BISCARINI E.(3); MAURIZI L.(2); NARDONI N.(2); TRIPPELLA C.(2); GOEPFERT S.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Philip Morris Italia s.r.l., via Po 11-13-15, 00198, Roma, Italy; (3) L’Agricola s.r.l., Bastia Umbra, Perugia, Italy
    Increasing climate instability could lead to local agricultural constraints, presenting a risk for volumes and quality of tobacco supply. Selecting and breeding tobacco varieties for the ability to perform in unfavourable water conditions becomes a ...
  2. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 24

    Downregulation of a putative nitrate transporter gene substantially reduces the accumulation of TSNAs in air-cured tobaccos

    GOEPFERT S.(1); BOVET L.(1); LU J.(2); CAMPANONI P.(1); LEWIS R.S.(2); DEWEY R.E.(2)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) North Carolina State University, Department of Crop Science, Raleigh, NC, U.S.A.
    Air-cured Burley tobacco leaves typically exhibit high levels of nicotine-derived nitrosamine ketone (NNK) and N'-nitrosonornicotine (NNN). It has been previously demonstrated that leaf nitrate accumulation in air-cured tobaccos serves as the source ...
  3. CORESTA Congress, Kunming, 2018, Agronomy/Phytopathology Groups, AP 49

    The influence of Nicotiana alata-derived introgression on plant malformations of tobacco breeding lines resistant to tomato spotted wilt virus

    KORBECKA-GLINKA G.(1); TROJAK-GOLUCH A.(1); DOROSZEWSKA T.(1); GOEPFERT S.(2)
    (1) Institute of Soil Science and Plant Cultivation - State Research Institute, Pulawy, Poland; (2) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Tomato spotted wilt virus (TSWV) is one of the most destructive viruses for tobacco cultivation. Cultivar “Polalta” carries a resistance gene introgressed from a wild species, Nicotiana alata, but the use of this cultivar in breeding is hampered by ...
  4. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, ST 04

    Assessing the cytotoxicity of e-liquids without the use of the neutral red uptake assay

    McHUGH D.; CUDAZZO G.; VANSCHEEUWIJCK P.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    As part of the pre-clinical assessment performed for consumer products in the tobacco industry, an in vitro assessment of a tobacco product’s cytotoxicity was performed using the neutral red uptake (NRU) assay. Since 2004, the CORESTA In Vitro Task Force ...
  5. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 01

    Cross-sectional surveys on the use of tobacco products in the general population and in users of IQOS in Germany, Italy, and London (2018-2020): introducing the study protocols

    SPONSIELLO-WANG Z.; LANGER P.; PRIETO L.; DOBRYNINA M.; SKIADA D.; CAMILLE N.; WEITKUNAT R.; LÜDICKE F.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Background: Philip Morris International (PMI) launched cross-sectional surveys in Italy, Germany, and London in March 2018 following the commercialization of a heat-not-burn tobacco product, IQOS. This publication introduces the study protocols. Methods: ...
  6. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 02

    Quantification of nitrogen oxides in aerosol of heat-not-burn IQOS product and combination of aerosol collection with the aerosol generation for TSNA analysis

    BADER P.; DEBRICK A.; GAUTIER L.; RADTKE F.; HUNKELER P.; MATERA R.; REYREN C.; CRENNA M.; STOOP A.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    Nitrogen oxides (NOx), nitrogen monoxide (NO), and tobacco-specific nitrosamines (TSNA) are compounds that are analysed in the mainstream aerosol of heat-not-burn tobacco products, such as IQOS. The purpose of this study was to develop and validate a ...
  7. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 03

    Determination of nicotine, eugenol, menthol and aerosol formers in tobacco products and materials

    BELLO J.; D’AGOSTINO A.; JUVET-PECALVEL C.; NAGANATHAN K.; ROTA C.; GAUTIER L.; O’REILLY C.; DUPASQUIER N.; YERLY M.
    Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland
    The purpose of this study was to validate a unique method that simultaneously determines the concentration of nicotine, eugenol, menthol, and glycerin in Reduced-Risk Products tobacco products [1], and menthol and triacetin in materials. Analytes are ...
  8. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 12 (also presented at TSRC 2018)

    Characterization of the Vitrocell® high throughput exposure modules using different tobacco product types

    LEVERETTE R.(1); KEYSER B.(2); SEYMOUR A.(2); HOLLINGS M.(2); BOMBICK B.(1)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    The development of whole smoke/aerosol exposure systems provides a means to conduct in vitro assessment of freshly generated whole smoke and aerosol from combustible and tobacco heating products (THP) as well as electronic nicotine delivery systems (ENDS) ...
  9. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 13 (also presented at TSRC 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 1. Mouse lymphoma assay

    LEVERETTE R.(1); THORNE D.(2); BREHENY D.(2); FOWLER K.(1); McENANEY S.(3); LLOYD M.(3); CLEMENTS J.(3); BOMBICK B.(1); GACA M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) British American Tobacco (Investments) Ltd., Southampton, U.K.; (3) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    In vitro studies have been widely used to support the toxicological evaluation of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from different tobacco and nicotine delivery products was assessed against ...
  10. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 14 (also presented at TSRC 2018)

    Genotoxicity evaluation of tobacco and nicotine delivery products: Part 2. In Vitro micronucleus assay

    LEVERETTE R.(1); THORNE D.(2); BREHENY D.(2); FOWLER K.(1); McENANEY S.(3); WHITWELL J.(3); CLEMENTS J.(3); BOMBICK B.(1); GACA M.(2)
    (1) RAI Services Company, Scientific & Regulatory Affairs, Winston-Salem, NC, U.S.A.; (2) British American Tobacco (Investments) Ltd., Southampton, U.K.; (3) Covance Laboratories Ltd, Harrogate, North Yorkshire, U.K.
    In vitro studies have been widely used to support toxicological evaluations of chemicals and complex mixtures including cigarette smoke. In this study a variety of test matrices from tobacco and nicotine delivery products were assessed against a 3R4F ...