1. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 02

    Contemporary high-content screening approaches to assess the biological impact of single compounds and complex mixtures in vitro

    FRENTZEL S.(1); THORNE D.(2); MARESCOTTI D.(1); TAYLOR M.(2); BOVARD D.(1); MORELLI M.(1); MATHIS C.(1); HOENG J.(1); GACA M.(2); PEITSCH M.C.(1); PROCTOR C.J.(2)
    (1) PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland; (2) British American Tobacco, R&D Centre, Southampton, U.K.
    High-content screening (HCS) is an automated image-based screening technology that allows analysing macroscopically the biological impact of single compounds or complex mixtures on cells growing in multi-well culture dishes. The technology involves...
  2. CORESTA Meeting, Smoke Science/Product Technology, 2019, Hamburg, STW 04

    Multi-organ-on-a-chip platforms to assess the biological impact of toxicants as well as PBPK properties in vitro

    FRENTZEL S.; BOVARD D.; SANDOZ A.; LUETTICH K.; HOENG J.; PEITSCH M.C.
    PMI R&D, Philip Morris Products S.A., Neuchâtel, Switzerland
    The merging of three-dimensional (3D) organotypic in vitro models with multi-organ-on-a-chip (MOC) technology has taken in vitro assessment of chemicals to an unprecedented level. By connecting multiple 3D organotypic models, MOCs enable the study of...
  3. CORESTA Congress, Kunming, 2018, Smoke Science/Product Technology Groups, STPOST 30

    Effects of exposure to e-cigarette aerosols compared with cigarette smoke on 3D human buccal and small airway cultures: a systems toxicology assessment

    ISKANDER A.(1); STEINER S.(1); MAJEED S.(1); KONDYLIS A.(1); XIANG Yang(1); ZANETTI F.(1); FRENTZEL S.(1); MARTIN F.(1); PEITSCH M.C.(1); DOSHI U.(2); McKINNEY W.J.(2); LEE K.M.(2); HOENG J.(1)
    (1) Philip Morris Products S.A. (part of Philip Morris International group of companies), PMI R&D, Neuchâtel, Switzerland; (2) Altria Client Services LLC, Research, Development & Regulatory Affairs, Richmond VA, U.S.A.
    Considerable attention has been given toward the reduced risk potential of e-cigarettes (e-cigs). Most in vitro studies have focused on testing e-liquid formulations directly on submerged 2D cultures. Here, we examined the effects of exposure to the...